Team 3- Cellular and molecular orchestration in muscle regeneration, during ageing and in pathologies

Team leader: Capucine Trollet

Our team is working on the molecular and cellular actors involved in human muscle regeneration, in muscle ageing and in muscular dystrophies including oculopharyngeal muscular dystrophy (OPMD) and Duchenne muscular dystrophy (DMD).

More precisely we are working on RNA metabolism, muscle regeneration, muscle stem cells, and fibrosis, with the final aim of developing innovative therapeutic approaches.

We have a strong expertise on human cellular models (this includes Myoline, the platform for immortalization that we have initiated) – and xenotransplantation (this includes several immunodeficient mouse models and grafting procedures).

 

Themes currently developed in parallel and in synergy

  1. Dissection of the molecular mechanisms relevant to OPMD and muscle ageing
  2. Dissection of cellular communication during muscle ageing, fibrosis and regeneration
  3. Development of therapeutic approaches.

 

 

Team members

Capucine Trollet (DR2 INSERM, team leader)
Nami Altin (IR)
Mona Bensalah (IR)
Maria Bergas Buades (PhD student)
Anne Bigot (CR AIM)
Dounia Bouragba (PhD student
Gillian S Butler-Browne (DR1 INSERM, Emeritus)
Rokiatou Diarra (L3 apprentice)
Valentine Hanique (IE)
Jean Lacau St Guily (PUPH, Emeritus)
Kamel Mamchaoui (IR AIM)
Barbara Moreira Crisol (postdoc)
Hadidja-Rose Mouigni (PhD student)
Vincent Mouly (DR1 CNRS, Emeritus)
Laura Muraine (IR)
Elisa Negroni (Sorbonne University Junior Professorship)
Jessica Ohana (Engineer)

Contacts

capucine.trollet@upmc.fr

 

Collaboration: France-Brazil International Associated Laboratory

Another specific aspect of our team is the development of international collaborations. In addition to numerous collaborations established over many years, we have set up an International Associated Laboratory between INSERM and Sorbonne University for France and FIOCRUZ and the Federal University of Rio de Janeiro for Brazil.

 

The IAL aims to synergise the expertise in muscle and neuromuscular diseases of French teams and the expertise in immunology and inflammation of the Brazilian teams.

The IAL has already been renewed once, has resulted in 14 publications and a common patent, as well as the exchange of three long-term post-docs, 5 jointly supervised PhDs and many short term exchanges, including visiting professorships in both countries. A common training component (masters and / or doctoral program) is being developed and will involve innovative Biotherapies in the muscle environment.

Figure legend: Human myoblasts in the damaged muscle of an immunodeficient mouse, identified by species-specific antibodies

 

 

Last publications