Co-team leaders : Harmen Reyngoudt & Benjamin Marty

Nuclear magnetic resonance (NMR) imaging and spectroscopy are powerful techniques that can be used to study muscle anatomy, physiology and biochemistry during one single examination.

In addition, muscle intrinsic contrast with NMR is incomparably richer than with other techniques and optimized radiofrequency pulse sequences allow quantifying specifically different variables, like the intramuscular fat fraction, muscle water relaxation times, muscle perfusion and oxygenation, which can be altered in patients with neuromuscular disorders.

Our laboratory focuses most of its efforts in the development of these quantitative NMR methods, their validation, their promotion and their implementation in mono-centric and multi-centric clinical trials related to neuromuscular disorder. These trials allow studying both the natural history of the pathology or the effect of a novel therapeutic approach.

More precisely, our research projects aim at:

• Developing novel NMR contrasts in preclinical and clinical settings aiming at detecting and quantifying different pathophysiological processes involved in the onset and progression of myopathies, like muscle inflammation, necrosis and fibrosis.
• Determining the prognostic value of these novel NMR variables on disease progression in several neuromuscular disorders
• Developing tools to investigate the muscle at exercise (non-magnetic ergometers, multinuclear interleaved data acquisitions, …).
• Accelerating NMR data acquisition using novel acquisition schemes (undersampled radial encoding) and multi-parametric data acquisitions (MR-fingerprinting, deep learning approaches, …).

Team members

Benjamin Marty, PhD, Co-teamleader
Harmen Reyngoudt, PhD, Co-teamleader

Isabelle Ackermann-Bonan, MD, radiologist
Pierre-Yves Baudin, Design engineer, PhD
Jean-Marc Boisserie, MRI technologist
Ericky Caldas de Almeida Araújo, PhD, Research associate
Julien Dousseau, Animal technician
Mathias Duventru, MRI technologist
Yves Fromes, MD, PhD, Physician, DR1
Eric Giacomini, Design engineer
Valentin Henriet, PhD student
Sophie Jouan, MRI technologist
Béatrice Matot, PhD, Research associate
Louis Rigler, PhD student
Constantin Slioussarenko, PhD student
Eléonore Vermeulen, PhD student

Contact

General informations: info_rmn@institut-myologie.org 

Last publications

• Höger, SA, Gast, LV, Marty, B, et al. Sodium and quantitative hydrogen parameter changes in muscle tissue after eccentric exercise and in delayed-onset muscle soreness assessed with magnetic resonance imaging. NMR in Biomedicine. 2023; 36( 2):e4840. doi:10.1002/nbm.4840
• Reyngoudt, H., Smith, F. E., Caldas de Almeida Araújo, E., Wilson, I., Fernández-Torrón, R., James, M. K., Moore, U. R., Díaz-Manera, J., Marty, B., Azzabou, N., Gordish, H., Rufibach, L., Hodgson, T., Wallace, D., Ward, L., Boisserie, J.-M., Le Louër, J., Hilsden, H., Sutherland, H., Canal, A., Hogrel, J.-Y., Jacobs, M., Stojkovic, T., Bushby, K., Mayhew, A., Jain Clinical Outcome Study for Dysferlinopathy consortium, Straub, V., Carlier, P. G., and Blamire, A. M. (2022) Three-year quantitative magnetic resonance imaging and phosphorus magnetic resonance spectroscopy study in lower limb muscle in dysferlinopathy, Journal of Cachexia, Sarcopenia and Muscle, 13, 1850– 1863
• Lopez Kolkovsky, AL, Carlier, PG, Marty, B, Meyerspeer, M. Interleaved and simultaneous multi-nuclear magnetic resonance in vivo. Review of principles, applications and potential. NMR in Biomedicine. 2022; 35( 10):e4735. doi:10.1002/nbm.4735
• Moore, U., Caldas de Almeida Araújo, E., Reyngoudt, H., Gordish-Dressman, H., Smith, F. E., Wilson, I., James, M., Mayhew, A., Rufibach, L., Day, J. W., Jones, K. J., Bharucha-Goebel, D. X., Salort-Campana, E., Pestronk, A., Walter, M. C., Paradas, C., Stojkovic, T., Mori-Yoshimura, M., Bravver, E., Pegoraro, E., Mendell, J. R., The Jain COS Consortium, Bushby, K., Blamire, A. M., Straub, V., Carlier, P. G., and Diaz-Manera, J. (2022) Water T2 could predict functional decline in patients with dysferlinopathy, Journal of Cachexia, Sarcopenia and Muscle, 13, 2888– 2897, doi: https://doi.org/10.1002/jcsm.13063
• Pinto MJ, Fromes Y, Ackermann-Bonan I, Leturcq F, Verebi C, Romero NB, Stojkovic T. Muscle MRI as a Diagnostic Challenge in Emery-Dreifuss Muscular Dystrophy. J Neuromuscul Dis. 2022;9(5):649-654. doi:10.3233/JND-220823. PMID: 36031908.
• Wilferth, T, Müller, M, Gast, LV, et al. Motion-corrected ²³Na MRI of the human brain using interleaved ¹H 3D navigator images. Magn Reson Med. 2022; 88: 309- 321. doi:10.1002/mrm.29221