Team 9- Signaling pathways & striated muscles

Team leader: Antoine Muchir, PhD

Striated muscles comprise approximately 40% of total body weight, contain 50–75% of all body proteins and contribute significantly to multiple bodily functions. Two types of striated muscles exist: skeletal and cardiac muscles. They share a common architecture characterized by a very particular and well-described arrangement of muscle cells and associated connective tissue.

Muscular dystrophies are a family of muscle diseases characterized by weakness and progressive muscle degeneration. At the skeletal muscle level, they are manifested by a decrease of muscle strength (muscular dystrophy), and a lack of mobility of the joints (muscle retractions) that begin in childhood or in young adults. In a few cases, the decrease in muscle strength results in a loss of independent walking, making it necessary to use an electric wheelchair to move. These are genetically inherited diseases. There are several forms that differ in the age of onset of symptoms, the nature of the affected muscles, and severity. At the cardiac level, the presence of abnormalities is observed at a more or less advanced age, mainly in the form of dilated cardiomyopathy which represents the main cause of death and the severity of these diseases. There is still no cure so far.

Our group is particularly interested in studying the molecular and cellular mechanisms involved in muscular dystrophies and cardiomyopathies. It seems important and necessary to increase our knowledge on the pathophysiology of these pathologies to unveil the cellular / molecular mechanisms that will make it possible to target future therapeutic approaches. We study in vitro and in vivo models of these pathologies and we develop new pharmacological therapies based on our findings.

 

 

AIM Equipe 9 – Voies de signalisation & muscles striés dirigée par Antoine Muchir le 30 avril 2024

Team members

Antoine MUCHIR, PhD, DR2, Team Leader
(google scholar : https://scholar.google.fr/citations?user=o2t5Nr0AAAAJ&hl=fr)
(ORCID : https://orcid.org/0000-0002-4780-9275)
Nicolas VIGNIER, PhD, CR
Bruno CADOT, PhD, CR
Cécile PECATTE, IE
Stéphanie BAUCHÉ, PhD, IR
Lorenzo GIORDANI, PhD, CRCN
Anne FORAND, PhD, Researcher
Elisabeth EUPHROSINE, PhD student
Chiara D’ERCOLE, PhD, Post-doc
Lucile SAILLARD, Ingénieure d’Études
Pritam SAHA, PhD student
Joana DA COSTA ORTERELO MARTINS, PhD student
Zoheir GUESMIA, IE (20%)

 

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