A review of the medical literature on cases of seronegative myasthenia gravis

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Patient reçu de nouveau en consultation par le Dr Jean-Baptiste Davion, neurologue, au sein du Centre de Référence des Maladies Neuromusculaires du CHU de Lille

Clinicians from Florence (Italy) have conducted a comprehensive analysis of the literature on so-called ‘seronegative’ myasthenia gravis, which is a relatively common presentation in clinical practice:

  • their work followed a PRISMA-style methodological approach and covered the period 2001–2024,
  • 31 studies, representing a total of 412 patients, were included in the review,
  • 67 per cent of the patients were women with a mean age of 42 years,
  • approximately half of them underwent selective verification of their seronegativity using other immunological techniques,
  • 43 per cent had developed a generalised form of myasthenia gravis,
  • 81 per cent received immunosuppressive treatment, with a significant proportion of refractory cases (24 per cent).

The authors emphasise the considerable variability in clinical presentations due to classification criteria that may differ from one team to another.

Clinical Characteristics and Treatment Management of Seronegative Myasthenia Gravis: A Systematic Review of the Literature. Verza MU, Schiavolin M, Beretta F et al. Muscle Nerve. 2026 Jul 1.

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