Identification of effective, non-invasive MRI markers in LGMD R9

French researchers from the Institute of Myology, Genethon and Atamyo, in collaboration with Dutch researchers, have studied several quantitative MRI parameters in order to identify sensitive and non-invasive biomarkers for assessing the progression of LGMD-R9 and evaluating the efficacy of new therapies.

Carried out in 18 persons with LGMD-R9 and 13 controls, this study shows that muscle fat fraction (MF), T2 water, T1 water and intramuscular pH are effective biomarkers for LGMD-R9. The correlation of some of the parameters tested suggests their potential in predicting disease progression.

Multi-parametric quantitative MRI of the lower limb muscles in a longitudinal study of limb-girdle muscular dystrophy R9. Rauh SS, Baudin PY, Stojkovic T, Birnbaum S, Decostre V, Zanfongnon RL, Fromes Y, Hooijmans MT, Strijkers GJ, Hogrel JY, Olivier S, Marty B, Reyngoudt H. PLoS One. 2025 Apr 28;20(4):e0321463. doi: 10.1371/journal.pone.0321463. eCollection 2025. PMID: 40293996