Creatine phosphokinase and creatine levels decrease with corticosteroid therapy in DMD

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American researchers studied over one year the variations of creatine phosphokinase (CPK) and creatine levels in a cohort of children and adolescents with Duchenne muscular dystrophy (DMD) receiving long-term glucocorticoids:

  • 555 DMD patients were included in the study.
  • CPK levels, blood and urine creatine levels, and the ratio of creatinineuria to urine osmolarity were measured repeatedly for 12 months.
  • CPK levels consistently followed a downward trend over time, correlating with deteriorating motor performance.
  • the annual slope of CPK decline was 14.7%, consistent with previous studies.

However, the authors emphasize the variations observed at the individual level, which limits the scope of these biomarkers.

 

A longitudinal study of creatine kinase and creatinine levels in Duchenne muscular dystrophy. Zygmunt AM, Wong BL, Horn PS et al. Muscle Nerve. 2022 Nov 28.

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