Bumetanide is not effective against focal paralysis attacks in hypokalemic periodic paralysis

A focal attack of paralysis induced by isometric exercise of the abductor muscle of the 5th finger of the hand followed by a period of rest according to the McManis protocol was induced in nine people with hypokalemic paralysis in a crossover trial of bumetanide versus placeboLe placebo est un produit dont la présentation est identique à celle d’un médicament, mais qui ne contient pas de principe actif. Dans un essai clinique, un placebo est utilisé pour mesurer l’action réelle du médicament testé, en comparant les effets du médicament testé contenant le principe actif et ceux du placebo..

• The amplitudes of the global muscle action potential of the abductor of the little finger measured within two hours and between the second and fourth hour after administration of 2mg bumetanide or placebo showed no significant difference between the two substances.
• Only two participants recovered from paralysis after taking bumetanide, none after taking placebo.

Bumetanide in Hypokalaemic Periodic Paralysis. on www.clinicaltrials.gov, accessed 06.03.2024

 

Crossover randomized controlled trial of bumetanide to rescue an attack of exercise induced hand weakness in hypokalaemic periodic paralysis. Scalco RS, Morrow JM, Manole A et al. Neuromuscul Disord. 2024 Feb;35:33-38.