Inflammatory myopathies: certain autoimmune conditions carry a significant risk of pulmonary complications

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Autoimmune conditions that test positive for anti-Ku antibodies carry a significant risk of pulmonary complications

Clinicians from ten centres within the Assistance-Publique Hôpitaux de Paris (APHP) compiled and compared the clinical and laboratory data of 154 adults with positive anti-Ku autoantibodies over the period 2010–2025:

  • 60 (40% of the sample) developed interstitial lung disease (ILD) at some point during their course of the disease,
  • chest imaging was analysed against international criteria for assessing the presence and progression of ILD,
  • the median age was 56 years,
  • the progression of ILD, measured over time, was associated with reduced survival, particularly in men.

This research, based on a large cohort, will help to better understand the natural history of this rare disease.

Characteristics and outcomes of anti-Ku antibody-associated interstitial lung disease: a retrospective study of 60 patients Robert M, Nguyen Y, Debray MP, et al. RMD Open. 2026 Jul 27;12(3)

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