institut de myologie, myology, Pitié-Salpêtrière, paris

Neuromuscular Physiology Laboratory

Jean-Yves-Hogrel-Laboratoire-de-physiologie-et-dévaluation-neuromusculaire-Institut-de-Myologie

Director : Dr Jean-Yves Hogrel

Our principal objectives are

  • To develop tools and evaluation methods of neuromuscular function. 
These tools and methods are necessary for the diagnosis of the disease and the follow-up of motor unit performances. This priority research orientation is justified by the need to improve the quantitative follow-up of patients, particularly for the evaluation of pharmacological, gene or cellular therapies.
  • To implement protocols allowing to emphasize and to better understand the physiological mechanisms at the origin of the functional modifications observed.
    These protocols could be exploited for therapeutic trials of neuromuscular diseases, but also in other situations such as surgery, ageing, hypokinesia or reconditioning.
  • Thanks to its maintenance, innovation and technology transfer activities, the Laboratory is examining the possibilities of valorisation and clinical transfer of new techniques and diagnostic and follow-up methods for neuromuscular pathologies.
  • The Laboratory is also working on the development of an Assurance/Quality referential. To our knowledge, a laboratory accredited in the field of functional explorations in the clinical environment does not exist. Nevertheless, it will be essential to guarantee the quality of neuromuscular force measurements during multicentric protocols whilst being based on validated procedures. 
By starting an Assurance/Quality approach, the Laboratory, aims to be the driving force behind a network of accredited centres.

 

Team members

  • Jean-Yves Hogrel, PhD, Biomedical Engineer, Laboratory director
  • Valérie Decostre, PhD, Physical therapist, Research fellow
  • Damien Bachasson, PhD, Physical therapist, Research fellow
  • Simone Birnbaum, PhD, Physical therapist, Research fellow
  • Erwan Gasnier, PhD, Project manager
  • Isabelle Ledoux, Biomedical Engineer
  • Aurélie Canal, Physical therapist
  • Thomas Poulard, PhD student
  • Alper Carras-Ayaz, Engineering student
  • Kevin Gramage-Medina, Masters student

 

Contact

+ 33 1 42 16 58 79

eval@institut-myologie.org

 

Clinical developments

The principal objective of the Neuromuscular Physiology and Evaluation Laboratory at the Institute of Myology is to develop tools and methods for the neuromuscular function evaluation. These tools and methods are necessary for the diagnosis of the disease and the reliable follow-up of motor performances in patients with neuromuscular disorders. This priority research orientation is justified by the need to improve the quantitative follow-up of patients, particularly for the assessment of pharmacological, gene or cellular therapies.

 

Neuromuscular strength assessment tools

MyoGrip - A dynamometer for high precision grip assessment (patented)

The MyoGrip dynamometer is an electronic device specifically developed for measuring isometric grip strength, even in the weakest patients. The MyoGrip was developed to meet the requirements of a quantified and rigorous monitoring of the grip strength, particularly in clinical trials.

The MyoGrip measures forces from 0 to 90 kg with a resolution of 10 g. Accuracy is 50 g. Handle size is adjustable in a continuous way.

Manufactured by Ateliers Laumonier (contact@ateliers-laumonier.fr)

 

  • This tool is involved in those protocols evaluation:

GSD III (Glycogénose)
Dynacure (Myopathie myotubulaire liée à l’X)
SOLID
ANTISENSE
Valerion-MTM (MTM)
Nathis-DMD (DMD)

  • Publications:

Seferian AM, Moraux A, Annoussamy M, Canal A, Decostre V, Diebate O, Le Moing AG, Deconinck N, Van Parys F, Vereecke W, Wittevrongel S, Mayer M, Maincent K, Desguerre I, Themar-Noel C, Cuisset JM, Tiffereau V, Denis S, Jousten V, Quijano-Roy S, Voit T, Hogrel JY, Servais L. Upper limb evaluation and one-year follow up of non-ambulant patients with Spinal Muscular Atrophy: An observational multicenter Trial. PLoS One;10(4):e0121799, 2015.

Seferian AM, Moraux A, Annoussamy M, Canal A, Decostre V, Diebate O, Le Moing AG, Deconinck N, Van Parys F, Vereecke W, Wittevrongel S, Mayer M, Maincent K, Desguerre I, Themar-Noel C, Cuisset JM, Tiffereau V, Denis S, Jousten V, Quijano-Roy S, Voit T, Hogrel JY, Servais L. Upper limb performance changes during a one-year follow-up in non-ambulant patients with Duchenne muscular dystrophy: an observational multicenter trial. PLoS One, 10(2):e0113999, 2015.

Hogrel JY, Allenbach Y, Canal A, Leroux G, Ollivier G, Mariampillai K, Servais L, Herson S, Decostre V, Benveniste O. Four-year longitudinal study of clinical and functional endpoints in sporadic Inclusion Body Myositis: implications for therapeutic trials. Neuromuscul Dis, 24:604-610, 2014.

Hogrel JY, Zagnoli F, Canal A, Fraysse B, Bouchard JP, Skuk D, Fardeau M, Tremblay JP. Assessment of a symptomatic Duchenne muscular dystrophy carrier 20 years after myoblast transplantation from her asymptomatic identical twin sister. Neuromuscul Dis, 23:575-579, 2013.

Servais L, Deconinck N, Moraux A, Benali M, Canal A, Van Parys F, Vereecke W, Wittevrongel S, Mayer M, Desguerre I, Maincent K, Themar-Noel C, Quijano-Roy S, Serari N, Voit T, Hogrel JY. Innovative methods to assess upper limb strength and function in non-ambulant Duchenne patients. Neuromuscul Disord, 23:139-148, 2013.

Allenbach Y, Benveniste O, Decostre V, Canal A, Eymard B, Herson S, Bloch-Queyrat C, Hogrel JY. Quadriceps strength is a sensitive marker of disease progression in sporadic inclusion body myositis. Neuromuscul Disord, 22:980–986, 2012.

Li K, Hogrel JY, Duchêne J, Hewson DJ. Analysis of fatigue and physiological tremor during sustained maximal grip contractions using Hilbert-Huang Transformation. Med Eng Phys, 34:832-840, 2012.

Li K, Hewson DJ, Duchêne J, Hogrel JY. Predicting maximal grip strength using hand circumference. Man Ther, 15:579-585, 2010.

Li K, Hewson DJ, Hogrel JY. Influence of elbow position and handle size on maximal grip strength. J Hand Surg, 34E:692-694, 2009.

MyoPinch - A dynamometer for the assessment of key pinch strength

The MyoPinch dynamometer measures pinch strength using a high precision load cell equipped with two steel blades presenting an overall thickness of 7 mm. The MyoPinch measures forces from 0 to 18 kg with a resolution of 1 g. Accuracy is 10 g. The MyoPinch was developed to meet the requirements of a quantified and rigorous monitoring of the pinch strength, particularly in clinical trials.

Manufactured by Ateliers Laumonier (contact@ateliers-laumonier.fr)

 

  • This tool is involved in those protocols evaluation:

Moonfish (Spinal muscular atrophy)
Sarepta (Duchenne Muscular Dystrophy)
NatHis-SMA (Spinal Muscular Atrophy)
Valerion-MTM (Myotubular myopathy)
ClinBio-GNE (Hereditary inclusion body myopathy)
Nathis-DMD (Duchenne muscular dystrophy)
PRO045 (Duchenne muscular dystrophy)
PRO053 (Duchenne muscular dystrophy)
Pre-U7-53 (Duchenne muscle dystrophy)
MyoTools (Normative database of distal dynamometers)

  • Publications:

Seferian AM, Moraux A, Annoussamy M, Canal A, Decostre V, Diebate O, Le Moing AG, Deconinck N, Van Parys F, Vereecke W, Wittevrongel S, Mayer M, Maincent K, Desguerre I, Themar-Noel C, Cuisset JM, Tiffereau V, Denis S, Jousten V, Quijano-Roy S, Voit T, Hogrel JY, Servais L. Upper limb evaluation and one-year follow up of non-ambulant patients with Spinal Muscular Atrophy: An observational multicenter Trial. PLoS One;10(4):e0121799, 2015.

Seferian AM, Moraux A, Annoussamy M, Canal A, Decostre V, Diebate O, Le Moing AG, Deconinck N, Van Parys F, Vereecke W, Wittevrongel S, Mayer M, Maincent K, Desguerre I, Themar-Noel C, Cuisset JM, Tiffereau V, Denis S, Jousten V, Quijano-Roy S, Voit T, Hogrel JY, Servais L. Upper limb performance changes during a one-year follow-up in non-ambulant patients with Duchenne muscular dystrophy: an observational multicenter trial. PLoS One, PLoS One, 10(2):e0113999, 2015.

Hogrel JY, Zagnoli F, Canal A, Fraysse B, Bouchard JP, Skuk D, Fardeau M, Tremblay JP. Assessment of a symptomatic Duchenne muscular dystrophy carrier 20 years after myoblast transplantation from her asymptomatic identical twin sister. Neuromuscul Dis, 23:575-579, 2013.

Servais L, Deconinck N, Moraux A, Benali M, Canal A, Van Parys F, Vereecke W, Wittevrongel S, Mayer M, Desguerre I, Maincent K, Themar-Noel C, Quijano-Roy S, Serari N, Voit T, Hogrel JY. Innovative methods to assess upper limb strength and function in non-ambulant Duchenne patients. Neuromuscul Disord, 23:139-148, 2013.

MyoAnkle - A dynamometer to assess the ankle flexion and extension strength

MyoAnkle - Dynamomètre pour l’évaluation de la force de flexion et d’extension de la chevilleThe MyoAnkle was developped to measure both dorsi-flexion and plantar-flexion strengths within a wide range of values, to provide good stabilization of the joint position and to be applicable to subjects of different statures. It can be used in patients with decreased muscle performance as well as healthy children and adults of all ages. The MyoAnkle was developed to meet the requirements of a quantified and rigorous monitoring of the ankle strength, particularly in clinical trials.

 

  • This tool is involved in those protocols evaluation:

MyoMet (A randomized, double blind, placebo-controlled phase II study of Metformin in Myotonic Dystrophy type I patients)

Hogrel JY, Allenbach Y, Canal A, Leroux G, Ollivier G, Mariampillai K, Servais L, Herson S, Decostre V, Benveniste O. Four-year longitudinal study of clinical and functional endpoints in sporadic Inclusion Body Myositis: implications for therapeutic trials. Neuromuscul Dis, 24:604-610, 2014.

Moraux A, Canal A, Ollivier G, Ledoux I, Doppler V, Payan C, Hogrel JY. Ankle dorsi- and plantar-flexion torques measured by dynamometry in healthy subjects from 5 to 80 years. BMC Musculoskel Dis, 14:104, 2013.

Allenbach Y, Benveniste O, Decostre V, Canal A, Eymard B, Herson S, Bloch-Queyrat C, Hogrel JY. Quadriceps strength is a sensitive marker of disease progression in sporadic inclusion body myositis. Neuromuscul Disord, 22:980–986, 2012.

MyoWrist - A dynamometer for wrist flexion and extension torque assessment

The MyoWrist is a highly sensitive device specifically designed for the assessment of both wrist flexion and extension torque with the same upper limb positioning in children and adults with the possibility of wrist angle adjustment for subjects with contractures. The MyoWrist was developed to meet the requirements of a quantified and rigorous monitoring of the wrist strength, particularly in clinical trials.

 

  • Publications:

Decostre V, Canal A, Ollivier G, Ledoux I, Moraux A, Doppler V, Payan C, Hogrel JY. Wrist flexion and extension torques measured by highly sensitive dynamometer in healthy subjects from 5 to 80 years. BMC Musculoskel Dis, 16(1):4, 2015.

Hogrel JY, Allenbach Y, Canal A, Leroux G, Ollivier G, Mariampillai K, Servais L, Herson S, Decostre V, Benveniste O. Four-year longitudinal study of clinical and functional endpoints in sporadic Inclusion Body Myositis: implications for therapeutic trials. Neuromuscul Dis, 24:604-610, 2014.

Hogrel JY, Zagnoli F, Canal A, Fraysse B, Bouchard JP, Skuk D, Fardeau M, Tremblay JP. Assessment of a symptomatic Duchenne muscular dystrophy carrier 20 years after myoblast transplantation from her asymptomatic identical twin sister. Neuromuscul Dis, 23:575-579, 2013.

Servais L, Deconinck N, Moraux A, Benali M, Canal A, Van Parys F, Vereecke W, Wittevrongel S, Mayer M, Desguerre I, Maincent K, Themar-Noel C, Quijano-Roy S, Serari N, Voit T, Hogrel JY. Innovative methods to assess upper limb strength and function in non-ambulant Duchenne patients. Neuromuscul Disord, 23:139-148, 2013.

Allenbach Y, Benveniste O, Decostre V, Canal A, Eymard B, Herson S, Bloch-Queyrat C, Hogrel JY. Quadriceps strength is a sensitive marker of disease progression in sporadic inclusion body myositis. Neuromuscul Disord, 22:980–986, 2012.

Herson S, Hentati F, Rigolet A, Behin A, B Romero NB, Leturcq F, Laforêt P, Maisonobe T, Amouri R, Haddad H, Audit M, Montus M, Masurier C, Gjata B, Georger C, Cheraï M, Carlier P, Hogrel JY, Herson A, Allenbach Y, M Lemoine FM, Klatzmann D, H Sweeney H, C. Mulligan RC, Eymard B, Caizergues D, Voit T, Benveniste O. A phase I trial of AAV1–γ-sarcoglycan gene therapy for limb girdle muscular dystrophy type 2C. Brain, 135:483-492, 2012.

Fardeau M, Braun S, Romero NB, Hogrel JY, Rouche A, Ortega V, Mourot B, Squiban P, Benveniste O, Herson S. About a phase I gene therapy clinical trial with a full-length dystrophin gene-plasmid in Duchenne/Becker muscular dystrophy. J Soc Biol, 199:29-32, 2005.

Romero NB, Braun S, Benveniste O, Leturcq F, Hogrel JY, Morris GE, Barois A, Eymard B, Payan C, Ortega V, Boch A-L, Lejean L, Thioudellet C, Mourot B, Escot C, Choquel A, Recan D, Kaplan J-C, Dickson G, Klatzmann D, Molinier-Frenckel V, Guillet J-G, Squiban P, Herson S, Fardeau M. Phase I Study of Dystrophin Plasmid-Based Gene Therapy in Duchenne/Becker Muscular Dystrophy. Hum Gene Ther,15:1065-1076, 2004.

Grip-ball - A grip handle for home training and monitoring (patented)

GripBall - Balle connectée pour la mesure et la rééducation de la force de préhension (breveté)

The Grip-ball is an innovative device that has been designed to measure grip strength. The Grip-ball consists of pressure and temperature sensors and an electronic wireless communication system contained in an airtight ball. The Grip-ball can be inflated to different initial pressures, with data available continuously in real time. The device has advantages over standard dynamometers in that it looks like a simple ball, and can wirelessly communicate via Bluetooth to any compatible receiver, thus have potential to be used for clinical assessment and rehabilitation in a remote setting.

 

Motor Function assessment devices

MoviPlate - A device for the assessment of upper limb motricity (patented)

The MoviPlate is a device that measure the ability to produce repeated movements of wrist and fingers between two cylindrical target keys aligned in the sagittal plane. The subject is asked to touch the two targets alternately as many times as possible in 30 seconds. Their detection threshold can be adjusted to the subject’s strength. Only back-and-forth taps are counted and displayed by the device. The MoviPlate was developed to meet the requirements of a quantified and rigorous monitoring of the upper limb motricity, particularly in clinical trials.

Manufactured by Valotec (contact@valotec.com)

 

  • This device is involved in those protocols evaluation:

NatHis-DM1 (Myotonic dystrophy type 1)
Pre-U7-53 (Duchenne muscular dystrophy)
Sarepta (Duchenne Muscular Dystrophy)
NatHis-SMA (Spinal Muscular Atrophy)
Valerion-MTM (Myotubular myopathy)
ClinBio-GNE (Hereditary inclusion body myopathy)
PRO053 (Duchenne muscular dystrophy)

  • Publications:

Seferian AM, Moraux A, Annoussamy M, Canal A, Decostre V, Diebate O, Le Moing AG, Deconinck N, Van Parys F, Vereecke W, Wittevrongel S, Mayer M, Maincent K, Desguerre I, Themar-Noel C, Cuisset JM, Tiffereau V, Denis S, Jousten V, Quijano-Roy S, Voit T, Hogrel JY, Servais L. Upper limb evaluation and one-year follow up of non-ambulant patients with Spinal Muscular Atrophy: An observational multicenter Trial. PLoS One;10(4):e0121799, 2015.

Seferian AM, Moraux A, Annoussamy M, Canal A, Decostre V, Diebate O, Le Moing AG, Deconinck N, Van Parys F, Vereecke W, Wittevrongel S, Mayer M, Maincent K, Desguerre I, Themar-Noel C, Cuisset JM, Tiffereau V, Denis S, Jousten V, Quijano-Roy S, Voit T, Hogrel JY, Servais L. Upper limb performance changes during a one-year follow-up in non-ambulant patients with Duchenne muscular dystrophy: an observational multicenter trial. PLoS One, PLoS One, 10(2):e0113999, 2015.

Hogrel JY, Zagnoli F, Canal A, Fraysse B, Bouchard JP, Skuk D, Fardeau M, Tremblay JP. Assessment of a symptomatic Duchenne muscular dystrophy carrier 20 years after myoblast transplantation from her asymptomatic identical twin sister. Neuromuscul Dis, 23:575-579, 2013.

Servais L, Deconinck N, Moraux A, Benali M, Canal A, Van Parys F, Vereecke W, Wittevrongel S, Mayer M, Desguerre I, Maincent K, Themar-Noel C, Quijano-Roy S, Serari N, Voit T, Hogrel JY. Innovative methods to assess upper limb strength and function in non-ambulant Duchenne patients. Neuromuscul Disord, 23:139-148, 2013.

ActiMyo - A device developed to evaluate the physical abilities of subjects suffering from neuromuscular or movement disorders at home

ActiMyo is a new device designed to assess patients with neuromuscular or movement disorders at home. It was developed to precisely record movement of upper and/or lower limbs in everyday life. ActiMyo is able to record the signals of any movement during a day, or for several consecutive days or weeks. ActiMyo measures the physical activity of a patient via various sensors in the three dimensional space.

  • This device is involved in those protocols evaluation:

Sarepta (Duchenne Muscular Dystrophy)
Valerion-MTM (Myotubular myopathy)
Nathis-DMD (Duchenne Muscular Dystrophy))
PRO045 (Duchenne muscular dystrophy)

Locometrix (Centaure Metrix) - Gait analysis using accelerometry

  • This device is involved in those protocols evaluation:

MGEX (Effect of training on quality of life in Myasthenia Gravis)
RAPAMI (Effect of Rapamycine in sporadic inclusion body myositis)
PRO053 (A Phase II/III, open-label, dose escalating with 48-week treatment study to assess the safety and tolerability, pharmacokinetics, pharmacodynamics and efficacy of PRO053 in subjects with Duchenne muscular dystrophy)
MyoMet (A randomized, double blind, placebo-controlled phase II study of Metformin in Myotonic Dystrophy type I patients)
NatHis-DM1 (Longitudinal assessment of the neuromuscular function in myotonic dystrophy type 1)
Accelerix (Gait analysis by accelerometry. Development of a normative database)

MyoTone Test - Quantitative myotonia assessment using force relaxation curve modeling

MyoTone Test - Evaluation de la myotonie par modélisation de la courbe de relaxation de forceThe MyoTone Test was developed in 2008 in order to assess in less than 10 min reaction time, maximal voluntary contraction (MVC) for hand grip and myotonia after a submaximal grip contraction at 70% MVC sustained during 5 sec. Myotonia is assessed using a fully automatic software based on mathematical modeling of relaxation force curve.

 

  • This tool is involved in those protocols evaluation:

MyoMet (Myotonic Dystrophy type 1)
NatHis-DM1 (Myotonic dystrophy type 1)
MyoMex (Efficacy and safety of mexiletine in non-dystrophic myotonias)

  • Publication:

Hogrel JY. Quantitative myotonia assessment using force relaxation curve modelling. Physiol Meas, 30:719–727, 2009.

HoBaMo system - Home Balance Monitoring system (patented)

HoBaMo system - Système de mesure de la qualité de l’équilibre à domicile (breveté)

  • Publications:

Hewson DJ, Duchêne J, Hogrel JY. Validation of balance-quality assessment using a modified bathroom scale. Physiol Meas, 36:207-218, 2015.

Michel-Pellegrino V, Li K, Hewson D, Hogrel JY, Duchêne J. Techniques d’évaluation à domicile de la qualité de l’équilibre et de la force de préhension chez la personne âgée en perte d’autonomie. IRBM, 30:262-267, 2009.

 

 

 

 

 

TaToo - Tremor assessment tool

TaToo - Outil d’évaluation des tremblements

 

Diagnostic devices

Grip Test - A non-ischemic forearm exercise test for the screening of patients with exercise intolerance

Grip TestThe Grip Test is a standardized non-ischemic exercise test used as a diagnostic tool for a safe screening of patients with exercise intolerance and for the diagnosis of various metabolic muscle disorders. The production of lactate, ammonia and creatine kinase are analyzed to guide the diagnosis. The sensitivity of the Grip Test is very good for patients with a glycogenolysis defect.

 

  • Publications:

Hogrel JY, van den Bogaart F, Ledoux I, Ollivier G, Petit F, Koujah N, Béhin A, Stojkovic T, Eymard B, Voermans N, Laforêt P. Diagnostic power of the non-ischaemic forearm exercise test in detecting glycogenosis type V. Eur J Neurol, 22(6):933-940. 2015.

Hogrel JY. Grip Test, test d’effort non ischémique de l’avant-bras : une aide au diagnostic. Cahiers de Myologie, 11:9-13, 2014.

Preisler N, Pradel A, Husu E, Madsen KL, Becquemin MH, Mollet A, Labrune P, Petit F, Hogrel JY, Jardel C, Maillot F, Vissing J, Laforêt P. Exercise intolerance in Glycogen Storage Disease Type III: Weakness or energy deficiency? Mol Genet Metab, 109:14-20, 2013.

Stojkovic T, Vissing J, Petit F, Piraud M, Orngreen MC, Andersen G, Claeys KG, Wary C, Hogrel JY, Laforêt P. Muscle glycogenosis due to phosphoglucomutase 1 deficiency. N Engl J Med, 361:425-427, 2009.

Ghosn J, Guiguet M, Jardel C, Benyaou R, Zeller V, Simon A, Valantin M-A, Amellal B, Assoumo L, Hogrel JY, Costagliola D, Katlama C, Lombès A. Muscle and liver lactate metabolism in HAART-treated and naive HIV-infected patients: the MITOVIR study. Antivir Ther, 10:543-550, 2005.

Hogrel JY, Laforêt P, Ben Yaou R, Chevrot M, Eymard B, Lombès A. A non-ischemic forearm exercise test for the screening of patients with exercise intolerance. Neurology, 56:1733-1738, 2001.

 

Muscle structure or composition assessment devices

Elastography of skeletal striated muscle

Aixplorer (Supersonic Imagine) - Dispositif pour l’évaluation de la raideur des muscles par élastographie (imagerie ultrarapide pour le suivi des ondes de cisaillement)A device for the assessment of stiffness of muscles using elastography (supersonic shear imaging)

 

  • Publications:

Lacourpaille L, Hug F, Guével A, Pereon Y, Magot A, Hogrel JY, Nordez A. Non-invasive assessment of muscle stiffness in patients with Duchenne Muscular Dystrophy. Muscle Nerve, 51:284-286, 2015.

Lacourpaille L, Hug F, Guével A, Pereon Y, Magot A, Hogrel JY, Nordez A. New insights on contraction efficiency in patients with Duchenne muscular dystrophy. J Appl Physiol (1985), 117:658-662, 2014.

Lacourpaille L, Hug F, Bouillard K, Hogrel JY, Nordez A. Supersonic shear imaging provides a reliable measurement of resting muscle shear elastic modulus. Physiol Meas, 33:N19-28, 2012.

 

 

 

 

A device for the assessment of bioimpedance (electrical measurement of physiological parameters)

> Access to the manufacturer Bioparhom
Dispositif pour l’évaluation de la bioimpédance globale et locale (propriétés électriques des tissus)

 

 

 

 

 

 

EMG – machine and software

ELAPS - High spatial resolution surface EMG electrodes (patented)

  • Système de mesure d’EMG à haute résolution spatiale Publications:

Hogrel JY. Introduction à la propagation des potentiels d’action musculaires. Cahiers de Myologie, 6:10-14, 2012.

Boërio D, Lefaucheur JP, Bassez G, Hogrel JY. Central and peripheral components of exercise-related fatigability in myotonic dystrophy type 1. Acta Neurol Scand, 125:38-46, 2012.

Hogrel JY, Ledoux I, Duchêne J. Reliability of muscle fibre conduction velocity distribution estimation from surface EMG. Biomed Sig Process Control, 3:118-125, 2008.

Ledoux I, Garcia Gonzales M-T, Duchêne J, Hogrel JY. Motor unit conduction velocity distribution estimation from evoked motor responses. IEEE Trans Biomed Eng, 53:608-616, 2006.

Hogrel JY. Clinical applications of surface electromyography in neuromuscular disorders. Neurophysiol Clin, 35:59-71, 2005.

Hogrel JY. Use of surface EMG for studying motor unit recruitment during isometric linear force ramp. J Electromyogr Kinesiol, 13:417-423, 2003.

Hogrel JY, Duchêne J. Motor unit conduction velocity distribution estimation: assessment of two short-term methods. Med & Biomed Eng & Comput, 40:253-259, 2002.

Hogrel JY, Duchêne J. A SEMG-based system for clinical applications using Laplacian electrodes. SENIAM, 4:172-177. 1999.

SiMyo - A software for EMG simulation

  • Logiciel pour la simulation de signaux EMGPublications:

Hogrel JY, Ledoux I, Duchêne J. Reliability of muscle fibre conduction velocity distribution estimation from surface EMG. Biomed Sig Process Control, 3:118-125, 2008.

Ledoux I, Garcia Gonzales M-T, Duchêne J, Hogrel JY. Motor unit conduction velocity distribution estimation from evoked motor responses. IEEE Trans Biomed Eng, 53:608-616, 2006.

Hogrel JY, Duchêne J. Motor unit conduction velocity distribution estimation: assessment of two short-term methods. Med & Biomed Eng & Comput, 40:253-259, 2002.

Duchêne J and Hogrel JY. A model of EMG generation. IEEE Trans Biomed Eng, 47:192-201, 2000.

 

 

Preclinical developments

 

DynaMice - An isometric dynamometer for the non-invasive assessment of flexion/extension torque of the ankle in small rodents

DynaMice - Dynamomètre pour l’évaluation de la force de flexion et d’extension de la cheville des petits rongeursDecostre V, Vignaud A, Matot B, Huguet A, Ledoux I, Bertil E, Gjata B, Carlier PG, Gourdon G, Hogrel JY. Longitudinal in vivo muscle function analysis of the DMSXL mouse model of myotonic dystrophy type 1. Neuromuscul Dis, 23:1016-1025, 2013.

Huguet A, Medja F, Nicole A, Vignaud A, Guiraud-Dogan C, Ferry A, Decostre V, Hogrel JY, Metzger F, Hoeflich A, Gomes-Pereira M, Puymirat J, Bassez G, Furling D, Munnich A, Gourdon G. Molecular, physiological and motor performance defects in DMSXL mice carrying >1000 CTG repeats from the human DM1 locus. PLOS Genet, 8:e1003043, 2012.


DynaDogs - In vivo measurement of wrist extension and flexion torque in the forelimb of the dog (patent pending)

Dynamomètre pour l’évaluation de la force de flexion et d’extension de la patte avant du chienLe Guiner C, Montus M, Servais L, Cherel Y, Francois V, Thibaud JL, Wary C, Matot B, Larcher T, Guigand L, Dutilleul M, Domenger C, Allais M, Beuvin M, Moraux A, Le Duff J, Devaux M, Jaulin N, Guilbaud M, Latournerie V, Veron P, Boutin S, Leborgne C, Desgue D, Deschamps JY, Moullec S, Fromes Y, Vulin A, Smith RH, Laroudie N, Barnay-Toutain F, Rivière C, Bucher S, Hoa Le T, Delaunay N, Gasmi M, Kotin RM, Bonne G, Adjali O, Masurier C, Hogrel JY, Carlier P, Moullier P, Voit T. Forelimb Treatment in a Large Cohort of Dystrophic Dogs Supports Delivery of a Recombinant AAV for Exon Skipping in Duchenne Patients. Mol Ther, 22:1923-1935, 2014.


Locometrix (Centaure Metrix) - Gait analysis using accelerometry

Locometrix (Centaure Metrix) - Dispositif accélérométrique pour l’analyse de la marcheBarthélémy I, Barrey E, Aguilar P, Le Chevoir M, Thibaud JL, Uriarte A, Voit T, Blot S, Hogrel JY. Longitudinal ambulatory measurements of gait abnormality in dystrophin-deficient dogs. BMC Musculoskel Dis, 12:75, 2011.

Barthélémy I, Barrey E, Thibaud JL, Uriarte A, Voit T, Blot S, Hogrel JY. Gait analysis using accelerometry in dystrophin-deficient dogs. Neuromuscul Disord, 19:788-796, 2009.

 

 

 

Recent publications

 

  • An embryonic CaVβ1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse. Traoré M, Gentil C, Benedetto C, Hogrel JY, De la Grange P, Cadot B, Benkhelifa-Ziyyat S, Julien L, Lemaitre M, Ferry A, Piétri-Rouxel F, Falcone S. Sci Trans Med, 11(517):eaaw1131, 2019.
  • Scapular dyskinesis in myotonic dystrophy type 1: clinical characteristics and genetic investigations. Voermans NC, van der Bilt RC, IJspeert J, Hogrel JY, Jeanpierre M, Behin A, Laforet P, Stojkovic T, van Engelen BG, Padberg GW, Sacconi S, Lemmers RJLF, van der Maarel SM, Eymard B, Bassez G. J Neurol. 2019 Dec;266(12):2987-2996.
  • Whole-body muscle magnetic resonance imaging in glycogen-storage disease type III. Tobaly D, Laforêt P, Perry A, Habes D, Labrune P, Decostre V, Masingue M, Petit F, Barp A, Bello L, Carlier P, Carlier RY. Muscle Nerve, 2019 Jul;60(1):72-79.
  • Large variation in effects during 10-years of enzyme-therapy in adults with Pompe disease. Harlaar L, Hogrel JY, Perniconi BP, Kruijshaar ME, Rizopoulos D, Taouagh N, Canal A, Brusse E, van Doorn PA, van der Ploeg AT, Laforêt P, van der Beek NAME. Neurology 2019 Nov 5;93(19):e1756-e1767.
  • ENMC workshop study group. 237th ENMC International Workshop: GNE myopathy – current and future research Hoofddorp, The Netherlands, 14-16 September 2018. Pogoryelova O, Urtizberea JA, Argov Z, Nishino I, Lochmüller H, Neuromuscul Disord. 29:401-410, 2019.
  • Hyperammonaemia following exercise may also reveal PGK1 deficiency. Hogrel JY, Ledoux I, Béhin A. J Clin Pathol, 72(6):452, 2019.
  • Ricotti V, Selby V, Ridout D, Domingos J, Decostre V, Mayhew A, Eagle M, Butler J, Guglieri M, Van der Holst M, Jansen M, Verschuuren JJGM, de Groot I, Niks E, Servais L, Straub V, Voit T, Hogrel JY, Muntoni F. Respiratory and upper limb outcome measures in ambulant and non-ambulant subjects with Duchenne muscular dystrophy: a prospective multicentre study. Neuromuscul Dis, 29(4):261-268, 2019.

  • Diaphragm shear modulus reflects transdiaphragmatic pressure during isovolumetric inspiratory efforts and ventilation against inspiratory loading. Bachasson D, Dres M, Niérat MC, Gennisson JL, Hogrel JY, Doorduin J, Similowski T. J App Physiol, 126(3):699-707, 2019.

  • X-linked Myotubular Myopathy: A prospective international natural history study. Annoussamy M, Lilien C, Gidaro T, Gargaun E, Chê V, Schara U, Gangfuß A, D’Amico A, Dowling JJ, Darras BT, Daron A, Hernandez A, de Lattre C, Arnal JM, Mayer M, Cuisset JM, Vuillerot C, Fontaine S, Bellance R, Biancalana V, Buj-Bello A, Hogrel JY, Landy H, Servais L. Neurology, 92:e1852-e1867, 2019.

  • Association of interleukin-6 rs1800796 polymorphism with reduced cognitive performance in healthy older adults. Bezuch NE, Bradburn S, Sipilä S, Pääsuke M, Gapeyeva H, Maier AB, Hogrel JY, Barnouin Y, Butler-Browne G, Narici M, McPhee J, Murgatroyd C. Meta Gene, 19:51-55, 2019.
  • 
Assessment of disease progression in dysferlinopathy – a one year cohort study. Moore U, Jacobs M, James MK, Mayhew AG, Fernandez-Torron R, Feng J, Cnaan A, Eagle M, Bettinson K, Rufibach LE, Muni Lofra R, Blamire AM, Carlier PG, Mittal P, Pax Lowes L, Alfano L, Rose K, Duong T, Berry KM, Montiel-Morillo E, Pedrosa-Hernández I, Holsten S, Sanjak M, Ashida A, Sakamoto C, Tateishi T, Yajima H, Canal A, Ollivier G, Decostre V, Bosco Mendez J, Sánchez-Aguilera Praxedes N, Thiele S, Siener C, Shierbecker J, Florence JM, Vandevelde B, DeWolf B, Hutchence M, Gee R, Prugel J, Maron E, Hilsden H, Lochmüller H, Grieben U, Spuler S, Tesi Rocha C, Day JW, Jones KJ, Bharucha-Goebel DX, Salort-Campana E , Harms M, Pestronk A, Krause S, Schreiber-Katz O, Walter MC, Paradas C, Hogrel JY, Stojkovic T, Takeda S, Mori-Yoshimura M, Bravver E, Sparks S, Díaz-Manera J, Bello L, Semplicini C, Pegoraro E, Mendell JR, Bushby K, Straub V, for the Jain COS Consortium. Neurology, 92:e461-e474, 2019.

  • The clinical and radiological landscape of adult spinal-muscular atrophy: a combined spinal and cerebral neuroimaging study. Querin G, El Mendili MM, Lenglet T, Behin A, Stojkovic T, Salachas F, Le Forestier N, del Mar Amador M, Debs R, Meininger V, Bruneteau G, Lehéricy S, Laforêt P, Blancho S, Benali H, Catala M, Marchand-Pauvert V, Hogrel JY, Bede P, Pradat PF. Neuroimage Clin, 21:101618, 2019.
  • 
Gagnon C, Heatwole C, Hébert LJ, Hogrel JY, Laberge L, Leone M, Meola G, Richer L, Sansone V, Kierkegaard M. Report of the third outcome measures in myotonic dystrophy type 1 (OMMYD-3) international workshop Paris, France, June 8, 2015. J Neuromuscul Dis, 5(4):523-537, 2018.
  • The motor unit number index (MUNIX) profile of patients with adult spinal muscular atrophy. Querin G, Lenglet T, Debs R, Stojkovic T, Behin A, Salachas F, Le Forestier N, Amador MDM, Lacomblez L, Meininger V, Bruneteau G, Laforêt P, Blancho S, Marchand-Pauvert V, Bede P, Hogrel JY, Pradat PF. Clin Neurophysiol. 2018 Sep 13;129(11):2333-2340. doi: 10.1016/j.clinph.2018.08.025. [Epub ahead of print]
  • Marathons and myasthenia gravis: a case report. Birnbaum S, Sharshar T, Eymard B, Theaudin M, Portero P, Hogrel JY. BMC Neurol. 2018 Sep 18;18(1):145. doi: 10.1186/s12883-018-1150-0.
  • Improved mobility with metformin in patients with myotonic dystrophy type 1: a randomized controlled trial. Bassez G, Audureau E, Hogrel JY, Arrouasse R, Baghdoyan S, Bhugaloo H, Gourlay-Chu ML, Le Corvoisier P, Peschanski M. Brain. 2018 Aug 29. doi: 10.1093/brain/awy231. [Epub ahead of print]
  • Late-onset Pompe disease in France: molecular features and epidemiology from a nationwide study. Semplicini C, Letard P, De Antonio M, Taouagh N, Perniconi B, Bouhour F, Echaniz-Laguna A, Orlikowski D, Sacconi S, Salort-Campana E, Solé G, Zagnoli F, Hamroun D, Froissart R, Caillaud C, Laforêt P; French Pompe Study Group. J Inherit Metab Dis. 2018 Aug 28. doi: 10.1007/s10545-018-0243-7. [Epub ahead of print]
  • Improved mobility with metformin in patients with myotonic dystrophy type 1: a randomized controlled trial. Bassez G, Audureau E, Hogrel JY, Arrouasse R, Baghdoyan S, Bhugaloo H, Gourlay-Chu ML, Le Corvoisier P, Peschanski M. Brain, 141(10):2855-2865, 2018.
  • Prospective and longitudinal natural history study of patients with Type 2 and 3 spinal muscular atrophy: Baseline data NatHis-SMA study. Chabanon A, Seferian AM, Daron A, Péréon Y, Cances C, Vuillerot C, De Waele L, Cuisset JM, Laugel V, Schara U, Gidaro T, Gilabert S, Hogrel JY, Baudin PY, Carlier P, Fournier E, Lowes LP, Hellbach N, Seabrook T, Toledano E, Annoussamy M, Servais L; NatHis-SMA study group. PLoS One. 2018 Jul 26;13(7):e0201004. doi: 10.1371/journal.pone.0201004. eCollection 2018.
  • Ankle strength impairments in myotonic dystrophy type 1: a five-year follow-up. Hébert LJ, Vial C, Hogrel JY, Puymirat J. J Neuromusc Dis, 5(3):321-330, 2018.
  • Handgrip Strength Cannot Be Assumed a Proxy for Overall Muscle Strength. Yeung SSY, Reijnierse EM, Trappenburg MC, Hogrel JY, McPhee JS, Piasecki M, Sipila S, Salpakoski A, Butler-Browne G, Pääsuke M, Gapeyeva H, Narici MV, Meskers CGM, Maier AB. J Am Med Dir Assoc. 2018 Aug;19(8):703-709. doi: 10.1016/j.jamda.2018.04.019. Epub 2018 Jun 20.
  • Muscle MRI in patients with dysferlinopathy: pattern recognition and implications for clinical trials. Diaz-Manera J, Fernandez-Torron R, LLauger J, James MK, Mayhew A, Smith FE, Moore UR, Blamire AM, Carlier PG, Rufibach L, Mittal P, Eagle M, Jacobs M, Hodgson T, Wallace D, Ward L, Smith M, Stramare R, Rampado A, Sato N, Tamaru T, Harwick B, Rico Gala S, Turk S, Coppenrath EM, Foster G, Bendahan D, Le Fur Y, Fricke ST, Otero H, Foster SL, Peduto A, Sawyer AM, Hilsden H, Lochmuller H, Grieben U, Spuler S, Tesi Rocha C, Day JW, Jones KJ, Bharucha-Goebel DX, Salort-Campana E, Harms M, Pestronk A, Krause S, Schreiber-Katz O, Walter MC, Paradas C, Hogrel JY, Stojkovic T, Takeda S, Mori-Yoshimura M, Bravver E, Sparks S, Bello L, Semplicini C, Pegoraro E, Mendell JR, Bushby K, Straub V; Jain COS Consortium. J Neurol Neurosurg Psychiatry. 2018 Oct;89(10):1071-1081. doi: 10.1136/jnnp-2017-317488. Epub 2018 May 7.
  • Muscle Shear Wave Elastography in Inclusion Body Myositis: Feasibility, Reliability and Relationships with Muscle Impairments. Bachasson D, Dubois GJR, Allenbach Y, Benveniste O, Hogrel JY. Ultrasound Med Biol. 2018 Jul;44(7):1423-1432. doi: 10.1016/j.ultrasmedbio.2018.03.026. Epub 2018 Apr 26.
  • Update on outcome assessment in myositis. Rider LG, Aggarwal R, Machado PM, Hogrel JY, Reed AM, Christopher-Stine L, Ruperto N. Nat Rev Rheumatol. 2018 May;14(5):303-318. doi: 10.1038/nrrheum.2018.33. Epub 2018 Apr 12. Review.
  • The Anisotropic Degree Index: a novel parameter to estimate muscle quality based on B-mode ultrasound images. Dubois GJR, Bachasson D, Lacourpaille L, Benveniste O, Hogrel JY. Ultrasound Med Biol. 2018 May;44(5):1133-1140. doi: 10.1016/j.ultrasmedbio.2017.12.017. Epub 2018 Feb 7.
  • Teenage exercise is associated with earlier symptom onset in dysferlinopathy: a retrospective cohort study. Moore UR, Jacobs M, Fernandez-Torron R, Jang J, James MK, Mayhew A, Rufibach L, Mittal P, Eagle M, Cnaan A, Carlier PG, Blamire A, Hilsden H, Lochmüller H, Grieben U, Spuler S, Tesi Rocha C, Day JW, Jones KJ, Bharucha-Goebel DX, Salort-Campana E, Harms M, Pestronk A, Krause S, Schreiber-Katz O, Walter MC, Paradas C, Hogrel JY, Stojkovic T, Takeda S, Mori-Yoshimura M, Bravver E, Sparks S, Diaz-Manera J, Bello L, Semplicini C, Pegoraro E, Mendell JR, Bushby K, Straub V. J Neurol Neurosurg Psychiatry. 2018 Jan 29. pii: jnnp-2017-317329. doi: 10.1136/jnnp-2017-317329. [Epub ahead of print] No abstract available.
  • The role of electrodiagnosis with long exercise test in mcardle disease. Semplicini C, Hézode-Arzel M, Laforêt P, Béhin A, Leonard-Louis S, Hogrel JY, Petit F, Eymard B, Stojkovic T, Fournier E. Muscle Nerve. 2018 Jan 19. doi: 10.1002/mus.26074. [Epub ahead of print]
  • The benefits and tolerance of exercise in myasthenia gravis (MGEX): study protocol for a randomised controlled trial. Birnbaum S, Hogrel JY, Porcher R, Portero P, Clair B, Eymard B, Demeret S, Bassez G, Gargiulo M, Louët E, Berrih-Aknin S, Jobic A, Aegerter P, Thoumie P, Sharshar T; MGEX Study Group. Trials. 2018 Jan 18;19(1):49. doi: 10.1186/s13063-017-2433-2.
  • Dysregulation of C-X-C motif ligand 10 during aging and association with cognitive performance. Bradburn S, McPhee J, Bagley L, Carroll M, Slevin M, Al-Shanti N, Barnouin Y, Hogrel JY, Pääsuke M, Gapeyeva H, Maier A, Sipilä S, Narici M, Robinson A, Mann D, Payton A, Pendleton N, Butler-Browne G, Murgatroyd C. Neurobiol Aging. 2018 Mar;63:54-64. doi: 10.1016/j.neurobiolaging.2017.11.009. Epub 2017 Nov 23.
  • A double-blind, placebo-controlled trial of triheptanoin in adult polyglucosan body disease and open-label, long-termoutcome. Schiffmann R, Wallace ME, Rinaldi D, Ledoux I, Luton MP, Coleman S, Akman HO, Martin K, Hogrel JY, Blankenship D, Turner J, Mochel F. J Inherit Metab Dis. 2018 Sep;41(5):877-883. doi: 10.1007/s10545-017-0103-x. Epub 2017 Nov 6.
  • Two new cases of mitochondrial myopathy with exercise intolerance, hyperlactatemia and cardiomyopathy, caused by recessive SLC25A4 mutations. Tosserams A, Papadopoulos C, Jardel C, Lemière I, Romero NB, De Lonlay P, Wahbi K, Voermans N, Hogrel JY, Laforêt P. Mitochondrion. 2018 Mar;39:26-29. doi: 10.1016/j.mito.2017.08.009. Epub 2017 Aug 18.
  • Physical Activity Monitoring: A Promising Outcome Measure in Idiopathic Inflammatory Myopathies. Bachasson D, Landon-Cardinal O, Benveniste O, Hogrel JY, Allenbach Y. Neurology, 2017 Jul 4;89(1):101-103. doi: 10.1212/WNL.0000000000004061.
  • The diagnostic value of hyperammonaemia induced by the non-ischaemic forearm exercise test. Hogrel JY, Janssen JB, Ledoux I, Ollivier G, Béhin A, Stojkovic T, Eymard B, Voermans NC, Laforet P. J Clin Pathol. 2017 Oct;70(10):896-898. doi: 10.1136/jclinpath-2017-204324.
  • Measuring Habitual Physical Activity in Neuromuscular Disorders: A Systematic Review. Jimenez-Moreno AC, Newman J, Charman SJ, Catt M, Trenell MI, Gorman GS, Hogrel JY, Lochmüller H. J Neuromuscul Dis. 2017;4(1):25-52. doi: 10.3233/JND-160195.
  • Long term longitudinal study of muscle function in patients with glycogen storage disease type IIIa. Decostre V, Laforêt P, De Antonio M, Kachetel K, Canal A, Ollivier G, Nadaj-Pakleza A, M. Petit FM, Wahbi K, Fayssoil A, Eymard B, Behin A, Labrune P, Hogrel JY. Mol Genet Metab, 122:108-116, 2017.
  • Effect of enzyme replacement therapy with alglucosidase alfa (Myozyme®) in 12 patients with advanced late-onset Pompe disease. Papadopoulos C, Orlikowski D, Prigent H, Lacour A, Tard C, Furby A, Praline J, Solé G, Hogrel JY, De Antonio M, Semplicini C, Deibener-Kaminsky J, Kaminsky P, Eymard B, Taouagh N, Perniconi B, Hamroun D, Laforêt P, the French Pompe Study Group. Mol Genet Metab, 122(1-2):80-85, 2017.
  • Circulating levels of Dickkopf-1, Osteoprotegerin and sclerostin are higher in old compared with young men and women and positively associated with whole-body bone mineral density in older adults.Coulson J, Bagley L, Barnouin Y, Bradburn S, Butler-Browne G, Gapeyeva H, Hogrel JY, Maden-Wilkinson T, Maier AB, Meskers C, Murgatroyd C, Narici M, Pääsuke M, Sassano S, Sipilä S, AL-Shanti N, Stenroth L, Jones DA, S McPhee JS.  Osteoporesis Int, 28(9):2683-2689, 2017.
  • Long-term microdystrophin gene therapy is effective in a canine model of Duchenne muscular dystrophy. Le Guiner C, Servais L, Montus M, Larcher T, Fraysse B, Moullec S, Allais M, François V, Dutilleul M, Malerba A, Koo T, Thibaut JL, Matot B, Devaux M, Le Duff J, Deschamps JY, Barthelemy I, Blot S, Testault I, Wahbi K, Ederhy S, Martin S, Veron P, Georger C, Athanasopoulos T, Masurier C, Mingozzi F, Carlier PG, Gjata B, Hogrel JY, Adjali O, Mavilio F, Voit T, Moullier P, Dickson G. Nat Comm, 8:16105, 2017.
  • Biomarkers predict outcome in Charcot Marie Tooth Disease 1A. Fledrich R, Mannil M, Leha Andreas, Ehbrecht C, Solari A, Pelayo-Negro AL, Berciano J, Schlotter-Weigel B, Schnizer T, Prukop T, Garcia-Angarita N, Czesnik D, Haberlová J, Mazanec R, Paulus W, Walter M, Hogrel JY, Dubourg O, Schenone A, Baets J, de Jonghe P, Shy M, Horvath Rita, Pareyson D, Seeman P, Young P, Sereda MW. J Neurol Neurosurg Psychiatry, 88(11):941-952, 2017.
  • Physical Activity Monitoring: A Promising Outcome Measure in Idiopathic Inflammatory Myopathies. Bachasson D, Landon-Cardinal O, Benveniste O, Hogrel JY, Allenbach Y. Neurology, 89(1):101-103, 2017.
  • The diagnostic value of hyperammonaemia induced by the non-ischaemic forearm exercise test. Hogrel JY, Janssen JB, Ledoux I, Ollivier G, Béhin A, Stojkovic T, Eymard B, Voermans NC, Laforet P.  J Clin Pathol, 70(10):896-898, 2017.
  • Gait characterization in golden retriever muscular dystrophy dogs using linear discriminant analysis.Fraysse B, Barthélémy I, Qannari EM, Rouger K, Thorin C, Blot S, Le Guiner C, Chérel Y, Hogrel JY.  BMC Musculoskelet Disord, 18:153, 2017.
  •  First International Workshop on Clinical trial readiness for sarcoglycanopathies, November 15 – 16, 2016 Evry, France. Jimenez-Moreno AC, Newman J, Charman SJ, Catt M, Trenell MI, Gorman GS, Hogrel JY, Lochmüller H. Measuring Habitual Physical Activity in Neuromuscular Disorders: A Systematic Review. J Neuromuscul Dis, 4:25-52, 2017.
    Marsolier J, Laforet P, Pegoraro E, Vissing J, Richard I and the Sarcoglycanopathies working group. Neuromuscul Dis, 27:683-692, 2017.
  • Coupling between skeletal muscle fiber size and capillarization is maintained during healthy aging. Barnouin Y, McPhee, JS, Butler-Browne G, Bosutti A, De Vito G, Narici M, Behin A, Hogrel JY, Degens H. J Cachex Sarcop Muscle, 8(4):647-659, 2017.
  • Effects of Duchenne muscular dystrophy on muscle stiffness and response to electrically-induced muscle contraction: a 12-month follow-up. Lacourpaille L, Gross R, Hug F, Guével A, Pereon Y, Magot A, Hogrel JY, Nordez A. Neuromuscul Dis, 27:214-220, 2017.
  • Systemic AAV8-mediated gene therapy drives whole-body correction of myotubular myopathy in dogs. Mack DL, Poulard K, Goddard M, Latournerie V, Snyder JM, Grange RW, Elverman MR, Denard J, Veron P, Buscara L, Le Bec C, Hogrel JY, Doering J, Meng H, Yang L, Liu F, O’Callaghan M, Gopal N, Kelly1 VE, Smith BK, Strande JL, Mavilio F, Beggs AH, Mingozzi F, Lawlor MW, Buj-Bello A, Childers MK. Mol Ther, 25:839-854, 2017.
  • Assessment of maximal handgrip strength: how many attempts are needed? Reijnierse EM, de Jong N, C. Trappenburg MC, Blauw GJ, Butler-Browne G, Gapeyeva H, Hogrel JY, McPhee JS, Narici MV, Sipilä S, Stenroth L, van Lummel RC, Pijnappels M, Meskers CGM, Maier AB. J Cachex Sarcop Muscle, 8(3):466-474, 2017.
  • Translation, cross-cultural adaptation, and validation of the french version of the 15-item Myasthenia Gravis Quality Of life scale. Birnbaum S, Ghout I, Demeret S, Bolgert F, Eymard B, Sharshar T, Portero P, Hogrel JY. Muscle Nerve. 2017 May;55(5):639-645. doi: 10.1002/mus.25381. Epub 2017 Jan 3.