A focal attack of paralysis induced by isometric exercise of the abductor muscle of the 5th finger of the hand followed by a period of rest according to the McManis protocol was induced in nine people with hypokalemic paralysis in a crossover trial of bumetanide versus placebo.
- The amplitudes of the global muscle action potential of the abductor of the little finger measured within two hours and between the second and fourth hour after administration of 2mg bumetanide or placebo showed no significant difference between the two substances.
- Only two participants recovered from paralysis after taking bumetanide, none after taking placebo.
Bumetanide in Hypokalaemic Periodic Paralysis. on www.clinicaltrials.gov, accessed 06.03.2024
