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In dystrophic mdx mouse, desmin prevents muscle wasting, exaggerated weakness and fragility and fatigue

Duchenne muscular dystrophy (DMD) is a serious neuromuscular disease caused by a dystrophin deficiency. Desmin, like dystrophin, is associated with costameric structures connecting the sarcomeres to the extracellular matrix which contributes to muscle function. In this study, French experts including researchers from the Institute of Myology tried to provide additional information on the roles of … [Read more]

What is the purpose of the exon 31 in the modelling of clathrin structures in muscle cells? – Interview with S. Vassilopoulos

Interview with Stéphane Vassilopoulos, researcher at the Muscle Organization & Therapy of Dominant Centronuclear Myopathy laboratory in Team 2 at the Institute of Myology Research Centre, headed by Marc Bitoun. He and his group are interested in the muscle cell membrane proteins, and more particularly in clathrin and its involvement in myopathies and just published … [Read more]

87 026 262 euros were raised for the 2019 Telethon!

Last December 6th and 7th, people all across France rallied in favour of the 2019 Telethon, with donations totalling 74.5 million euros by the end of the television broadcast. Today, a few months later, we are very proud to announce the final result of our 2019 fundraising campaign: 87 026 262 euros. Thank you from … [Read more]

The neurospecific expression of SMN is necessary but not sufficient for the survival of SMA mice – Interview with M.G. Biferi & A. Besse

Interview with Maria-Grazia Biferi, Head of the BOND team (Motor-neurone disease [ALS & SMA] biotherapies team) and Aurore Besse, Preclinical Project Manager at the Institute of Myology. What are the origins of the project? This project started as a doctoral thesis by Aurore Besse and, with great teamwork, resulted in publication last May in Molecular … [Read more]

COVID-19, consultations and clinical trials: 6 questions for Dominique Duchêne

Dominique Duchêne, Project Manager, Clinical Research Associate (CRA) Manager at I-Motion, the paediatric clinical trial platform.

 If I could ask you who you are and what your mission is, and how long you have been working at the Institute? I joined the Institute of Myology in 2011 and I am currently Project Manager at I-Motion. … [Read more]

COVID-19 and the organisation of the neuromyology consultation – 5 questions for Isabelle Coupa

Interview with Isabelle Coupa, Nursing Manager at the Institute of Myology’s Service of Neuro-Myology. If I could ask you who you are and what your mission is? I am Isabelle Coupa, Nursing Manager at the Institute of Myology’s Service of Neuro-Myology. I hold a University Degree in Nursing and I have worked for a number … [Read more]

Release of the 79th newsletter from the Institute

The Institute of Myology teams fully mobilised!   Welcome to our 79th newsletter.   After these last weeks of confinement, Dr. Vincent Varlet, Secretary General of the Institute of Myology, and Pr. Bertrand Fontaine, Medical and Scientific Director of the Institute of Myology, Head of the service of Neuro-Myology and Director of the Myology Centre … [Read more]

Efgartigimod in Myasthenia gravis : the ADAPT phase III trial would have met its primary efficacy endpoint

An immunomodulatory biotherapy, efgartigimod is a fragment of antibodies directed against the neonatal Fc or FcRn receptors. These receptors prevent the breakdown of immunoglobulins G (IgG), which include the autoantibodies produced in myasthenia gravis. By binding to FcRn, efgartigimod (or ARGX-113) reduces the recycling of IgG and therefore their circulating rate. Administered as an infusion … [Read more]

COVID-19 and clinical trials in adults – 6 questions for Kubéraka Mariampillai

Interview with Kubéraka Mariampillai, Project Manager for the Adult Clinical Trials platform at the Institute of Myology, headed by Prof. Bertrand Fontaine and coordinated by Dr Giorgia Querin, and member of “Inflammatory Myopathies and Innovative Targeted Therapies” team 8 at the Research Centre, headed by Prof. Olivier Benveniste. If you could tell me who you … [Read more]

COVID-19 and psychological counselling : 5 questions for Prof. Marcela Gargiulo

Interview with Prof. Marcela Gargiulo, psychologist and leader of the team of psychologists at the Service of Neuro-Myology, headed by Prof. Bertrand Fontaine. If I could ask you who you are and what your mission is? I am a clinical psychologist and I have been working at the Institute of Myology since it was created … [Read more]