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Characterisation of PABPN1 aggregates in OPMD – Interview with Capucine Trollet

The results of an international study conducted by the Institute’s Capucine Trollet and Vincent Mouly team have just been published in Acta Neuropathologica. The article relates to the characterisation of PABPN1 aggregates performed on a unique series of 90 muscle biopsies from OPMD patients, collected from clinicians in France, Canada, the Netherlands and Israel, and on … [Read more]

A tool to evaluate cardiac risk in patients with mitochondrial disease – Interview with Karim Wahbi

Prof. Karim Wahbi, a cardiologist, has just published the results of an international study that he coordinated with his “Registries and databases” team at the Institute. The article relates to the prediction of cardiac consequences (complications) in adult patients with mitochondrial diseases*. What is the background to your conduct of this work? We have been … [Read more]

DM1: RNA toxicity alters astrocyte morphology, adhesion and migration

Mario Gomes-Pereira and his team* have just published a paper in Nature Communications** on the toxicity of mutant RNA that alters the morphology, adhesion and migration of astrocytes in mice and humans with myotonic dystrophy type 1 (DM1). Interview with Mario Gomes-Pereira.   What is the background to this work? DM1 is a neuromuscular disease … [Read more]

Report of the 2022 AcadeMYO session

Andoni Urtizberea reports on the 2022 session of AcadeMYO, the fully virtual version of the Institute’s Myology Summer School, which was held from 11 to 13 July. What was the profile of the students who participated this year? We had 44 registered participants from 27 countries: Chile, Argentina, Brazil, Colombia, Russia, Latvia, USA, Canada, Australia, … [Read more]

Identification of a new communication pathway in the neuromuscular junction

A study conducted by the “Neuromuscular connectivity in health and pathologies” team led by Laure Strochlic and Bertrand Fontaine at the Institute’s Myology Centre for Research has just been published in Science Signaling*. This work demonstrates the existence of a new communication pathway in the neuromuscular junction that is active both during embryogenesis and at … [Read more]

Endothelin: a new player in muscle fibrosis

Mona Bensalah completed her thesis under the supervision of Elisa Negroni and Vincent Mouly in the team “Cellular and molecular orchestration in muscle regeneration, during aging and in pathologies” directed by Capucine Trollet and Vincent Mouly, at the Institute’s Myology Research Centre. Her work, completed by that of Laura Muraine, has just been published in … [Read more]

My thesis in 180 seconds: Louison Lallemant, 2022 Public prize winner

Louison Lallemant is a doctoral student in the group of Mario Gomes-Pereira and Geneviève Gourdon within the REDs team led by Denis Furling and Geneviève Gourdon, at the Institute’s Myology Centre for Research. She has just won the Public Prize awarded by Internet users and the public attending the Sorbonne University Final of the “My … [Read more]

A new approach to gene therapy for Steinert’s disease

The Denis Furling* team (Paris, France), in collaboration with the Nicolas Sergeant** team (Lille, France), has developed and tested a new approach to gene therapy, a so-called “decoy” approach, for Steinert’s disease or myotonic dystrophy type 1 (DM1). The strategy is based on the expression of modified proteins that will bind to the pathological expansions … [Read more]

Charles Frison-Roche wins Oral Research Communication Prize awarded by SFM

Charles Frison-Roche has received the Oral Research Communication Prize, awarded by the French Myology Society (SFM). He is a PhD student in the REDs team headed by Denis Furling and Geneviève Gourdon, at the Myology Research Centre and the Institute of Myology. Under the supervision of Frédérique Rau, he is working on the pathophysiology of … [Read more]

The Institute has acquired a state-of-the-art electron microscope

Interview with Norma B. Romero and Stéphane Vassilopoulos Since July 2021, researchers, doctors and engineers/ technicians from the Institute of Myology have been learning to use the different functions of the new state-of-the-art transmission electron microscope that the Institute has just acquired. While all the teams at the Myology Research Centre and the Institute’s Morphology … [Read more]