Lamotrigine appears to be effective over two years in channelopathies

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Used as an alternative to mexiletine in the treatment of non-dystrophic myotonia, lamotrigine shows lasting efficacy in a new British study:

  • it involved 37 patients with non-dystrophic myotonia, 23 with a mutation in the CLCN1 gene and 14 in the SCN4A gene,
  • they received lamotrigine for an average period of 26 months,
  • the treatment resulted in a significant improvement in symptoms, with a decrease in the myotonia score,
  • however, 9 patients had to stop treatment due to headaches or severe skin rashes.

 

Long term safety and efficacy of lamotrigine in patients with non-dystrophic myotonia, a single-centre prospective study. Asad M, Skorupinska I, James N et al. Neuromuscul Disord. 2025 Nov

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