Changes in respiratory function in adults with SMA treated with nusinersen

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German clinicians studied the respiratory parameters of 192 adult patients with SMA receiving nusinersen treatment:

  • patients had been treated for an average of 3.2 years,
  • several spirometry tests had been performed during this period and were correlated with each patient’s functional motor status,
  • ventilatory parameters remained stable throughout the treatment period, with minimal deterioration,
  • the authors were unable to establish any discriminating factors such as age, ambulatory status or type of SMA.

This respiratory stability is likely to be related to treatment with nusinersen.

 

Respiratory function in 192 adult patients with spinal muscular atrophy (SMA) treated with nusinersen – a multicenter observational study. Wurster CD, Stolte B, Kessler T et al. Orphanet J Rare Dis. 2025 Sep.

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