Spinal cord organoids developed for SMA

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In recent years, the development of organoids, small 3D structures that resemble the whole organ, has enabled us to understand how they develop and function.

  • German researchers have developed spinal cord organoids in SMA, using patient-derived IPS cell lines.
  • These spinal cord organoids show defects in early neurological development that could be responsible for the loss of motor neurons later on.

 

Isogenic patient-derived organoids reveal early neurodevelopmental defects in spinal muscular atrophy initiation. Grass T, Dokuzluoglu Z, Buchner F et al. Cell Rep Med. 2024 Aug.

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