An early marker of myocardial damage in DMD

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Catalan clinicians have studied the possibility of early detection of myocardial alterations in Duchenne muscular dystrophy (DMD):

  • 23 adolescents with dystrophinopathy (14 DMD, 8 Becker, 1 symptomatic transmitter) were assessed using cardiac magnetic resonance imaging (cardio-MRI) and cardiac functional parameters,
  • their data were compared with a control group of 173 healthy individuals,
  • the analysis was used to draw up topographical maps of myocardial damage,
  • a notable asymmetry of this damage was observed between the septum and the region of the posterior wall of the left ventricle,
  • this asymmetry appears to correlate well with the reduction in systolic ejection fraction.

This non-invasive biomarker, although imperfect, could be useful for anticipating deterioration in cardiac function in DMD.

 

Asymmetric Myocardial Involvement as an Early Indicator of Cardiac Dysfunction in Pediatric Dystrophinopathies: A Study on Cardiac Magnetic Resonance (CMR) Parametric Mappings. Esmel-Vilomara R, Riaza L, Costa-Comellas L et al. Pediatr Cardiol. 2024 Apr 30.

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