Proper use of paracetamol prescriptions in SMA

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Following problems of drug intolerance in patients with SMA who had received paracetamol for pain relief, Danish researchers undertook a pharmacokinetic study:

  • six children and six adults with SMA were included and compared with eleven healthy subjects,
  • all were given paracetamol at the usual recommended doses,
  • repeated serum determinations of several paracetamol metabolites and hepatic biomarkers were used to calculate the product’s elimination slope,
  • paracetamol clearance is clearly reduced in patients with SMA,
  • one patient even experienced a significant increase in liver transaminase levels with this treatment.

The authors recommend reducing the dose in this at-risk population (15 mg/kg/take, up to a maximum of 4 grams daily).

 

Acetaminophen treatment in children and adults with spinal muscular atrophy: a lower tolerance and higher risk of hepatotoxicity. Naume MM, Zhao Q, Haslund-Krog SS et al. Neuromuscul Disord. 2024 Janv.

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