Protective effect of metformin on fibroblasts with GNE myopathy by restoring autophagic flux

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A Chinese team has studied autophagic flow, which is involved in the formation of bordered vacuoles, in fibroblast cultures from people with GNE myopathy :

  • autophagic flow is impaired;
  • It is improved by metformin administration;
  • the cellular protection of fibroblasts with GNE myopathy by metformin is independent of the AMPK-mTOR signalling pathway.

 

Metformin protects fibroblasts from patients with GNE myopathy by restoring autophagic flux via an AMPK/mTOR-independent pathway. Zhang T, Yin X, Yu X et al. Biomed Pharmacother. 2023 Aug;164:114958.

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