Technical platforms

The Institute of Myology shares parts of its expertise in the area of research, but also in the area of data processing and the conduct of clinical trials.


Biological Resource Centre

The Institute is a biological resource centre, making available immortalised cell lines and also tissue samples, intended exclusively for use in research.

  • Three teams are working on the Cell line platform, headed by Vincent Mouly, PhD (Joint Head of the Cell and Molecular Orchestration in Muscle Regeneration, Ageing and Diseases team, at the Myology Centre for Research), which offers more than 85 immortalised human cell lines from control or pathological subjects. Over 20 distinct diseases have been immortalised, with several different mutations for some of these.
  • The MYOBANK-AFM tissue bank, headed by Prof. Bertrand Fontaine (Scientific and Medical Director of the Institute of Myology and Head of the Service of Neuro-Myology) is a not-for-profit service, responsible for collecting, preparing, storing and distributing human tissue samples. The tissue samples come mainly from patients with rare or neuromuscular diseases, but also from healthy subjects, in order to provide a batch of “control” samples.


MyoTools assessment tools

The main objective of the Neuromuscular Physiology Laboratory headed by Jean-Yves Hogrel, PhD, is to develop tools and software to assess muscle strength in different systems (thumb-index pinch, knee flexor-extensor, etc.), movement, and resistance to fatigue.  These tools and methods are necessary in disease diagnosis and patient motor performance follow-up, especially in the context of assessing pharmacological, gene or cell therapies.


Registers and clinical trials

As of 2020, the Institute of Myology has a scientific and technological platform at its disposal that is allowing it to conduct around 30 research protocols: natural histories, treatment methodologies, exercise retraining and therapeutic trials (pharmacology, cell therapy, gene therapy and enzyme therapy). This platform is internationally recognised, and a number of pharmaceutical organisations and companies (the US NIH, Genzyme, PTC Therapeutics, Santhera, Roche, etc.) have chosen it as a primary investigator centre for some of their trials.

  • I-Motion Children, headed by Prof. Odile Boespflug-Tanguy (Paediatric Neurologist at the Robert Debré Hospital, Chair of the AFM-Téléthon Scientific Advisory Board), is the Institute’s paediatric clinical trial platform for neuromuscular diseases. Located at the site of the Trousseau Paediatric Hospital, it allows young patients to be cared for under the best conditions, in a tailored, welcoming and secure environment.
  • I-Motion Adults, headed by Prof. Bertrand Fontaine (Scientific and Medical Director of the Institute of Myology and Head of the Service of Neuro-Myology), is the adult clinical trial centre that operates for the purposes of interventional research in adults relating to therapeutic trials, natural histories and medical devices. It is located at the site of the Pitié-Salpêtrière Hospital.
  • The goal of the Registers and Databases Centre, headed by Dr Karim Wahbi, is the development and maintenance of databases, registers, observational studies and cohort follow-ups. The objective is to collect epidemiological data and natural histories, and to assess the effect of treatments and prepare future therapeutic trials.



The Institute of Myology holds a portfolio of patents relating to inventions developed in its laboratories.