Head: Prof. Bertrand Fontaine
Co-head: Dr Giorgia Querin

The Adult Clinical Trials centre is dedicated to clinical research in adults focusing on therapeutic trials, natural histories, medical devices and observational studies. 

The I-Motion Adults platform is located in the Babinski building on the site of the Pitié-Salpêtrière University Hospital and works in close collaboration with the Service of Neuro-Myology headed by Professor Bertrand Fontaine and with the different poles of the Hospital and research laboratories from the Institute of Myology. 

The team consists of a clinical studies doctor, a project manager and two clinical research associates. 

Currently 12 industrial intervention studies, 12 academic intervention studies and 12 non-interventional studies are underway. 

Team members

Prof. Bertrand Fontaine, MD, PhD, neuromyologist
Dr Giorgia Querin, MD, PhD, neurologist
Kubéraka Mariampillai, PhD, project manager

Saadane Kirouani, Clinical Research Associate (CRA)
Dina Ferhat, Clinical Research Associate (CRA)
Soumeya Hammal, Clinical Research Associate (CRA)

Key publications

• Querin G, Lenglet T, Debs R, Stojkovic T, Behin A, Salachas F, Le Forestier N, Amador MDM, Bruneteau G, Laforêt P, Blancho S, Marchand Pauvert V, Bede P, Hogrel JY, Pradat PF. Development of new outcome measures for adult SMA type III and IV a multimodal longitudinal study.  J Neurol 2021. doi 10 1007 /s 00415 020 10332 5
• Dewan R, et al. Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis. Neuron 2020 S0896-273(20)30883-7. doi :10.1016/j neuron.2020.11.005
• Cappella M, Pradat PF, Querin G, Biferi MG. Beyond the Traditional Clinical Trials for Amyotrophic Lateral Sclerosis and The Future Impact of Gene Therapy. J Neuromuscul Dis 2021 ; 8(1) : 25-38 doi : 10.3233/JND 20053
• Guimarães Costa R, Fernández Eulate G, Wahbi K, Leturcq F, Malfatti E, Behin A, Leonard Louis S, Desguerre I, Barnerias C, Nougues MC, Isapof A, Estournet Mathiaud B, Quijano Roy S, Fayssoil A, Orlikowski D, Fauroux B, Richard I, Semplicini C, Romero NB, Querin G, Eymard B, Laforêt P, Stojkovic T. Clinical correlations and long term follow up in 100 patients with sarcoglycanopathies. Eur J Neurol 2021 ; 28(2) : 660-669 doi : 10/1111/ene 14592
• Schito P, Ceccardi G, Calvo A, Falzone YM, Moglia C, Lunetta C, Marinou K, Ticozzi N, Scialo C, Sorarù G, Trojsi F, Conte A, Tortelli R, Russo M, Zucchi E, Pozzi L, Domi T, Carrera P, Agosta F, Quattrini A, Fazio R, Chiò A, Sansone VA, Mora G, Silani V, Volanti P, Caponnetto C, Querin G, Tedeschi G, Sabatelli M, Logroscino G, Messina S, Mandrioli J, Riva N, Filippi M. Clinical features and outcomes of the flail arm and flail leg and pure lower motor neuron MND variants a multicentre Italian study. J Neurol Neurosurg Psychiatry 2020 ; 91(9) : 1001-1003 doi : 10.1136/jnnp 2020 323542
• Schijven D, et al. Analysis of shared common genetic risk between amyotrophic lateral sclerosis and epilepsy. Neurobiol Aging 2020, 92 :153e-1 153e5 doi : 10.1016/j neurobiolaging.2020.04.011
• Abidi M, de Marco G, Grami F, Termoz N, Couillandre A, Querin G, Bede P, Pradat PF. Neural Correlates of Motor Imagery of Gait in Amyotrophic Lateral Sclerosis. J Magn Reson Imaging 2021, 53(1) : 223-233. doi : 10.1002/jmri 27335
• de Borba FC, Querin G, França MC Jr, Pradat PF. Cerebellar degeneration in adult spinal muscular atrophy patients. J Neurol 2020, 267(9) : 2625-2631. Doi : 10.1007/s.00415.020.09875.4
• Pradat PF, Bernard E, Corcia P, Couratier P, Jublanc C, Querin G, Morélot Panzini C, Salachas F, Vial C, Wahbi K, Bede P, Desnuelle C, French Kennedy’s Disease Writing Group. The French national protocol for Kennedy’s disease (consensus diagnostic and management recommendations). Orphanet J Rare Dis 2020 ; 15(1) : 90. doi :10.1186/s.13023.020.01366.z
• Allenbach Y, Uzunhan Y, Toquet S, Leroux G, Gallay L, Marquet A, Meyer A, Guillaud C, Limal N, Gagnadoux F, Hervier B, Borie R, Deligny C, Terrier B, Berezne A, Audia S, Champtiaux N, Devilliers H, Voermans N, Diot E, Servettaz A, Marhadour T, Castelain V, Humbert S, Blanchard-Delaunay C, Tieulie N, Charles P, Gerin M, Mekinian A, Priou P, Meurice JC, Tazi A, Cottin V, Miyara M, Grange B, Israël-Biet D, Phin-Huynh S, Bron C, De Saint Martin L, Fabien N, Mariampillai K, Nunes H, Benveniste O; French Myositis Network. Different phenotypes in dermatomyositis associated with anti-MDA5 antibody: Study of 121 cases. Neurology. 2020 Jul 7;95(1):e70-e78.
• Wesner N, Uruha A, Suzuki S, Mariampillai K, Granger B, Champtiaux N, Rigolet A, Schoindre Y, Lejeune S, Guillaume-Jugnot P, Vautier M, Hervier B, Simon A, Granier F, Gallay L, Nishino I, Benveniste O, Allenbach Y. Anti-RNP antibodies delineate a subgroup of myositis: A systematic retrospective study on 46 patients. Autoimmun Rev. 2020 Mar;19(3):102465.
• Monseau G, Landon-Cardinal O, Stenzel W, Schoindre Y, Mariampillai K, Barete S, Martel C, Masseau A, Meyer A, Terrier B, Guégan S, Verneuil L, Audia S, Livideanu CB, Hachulla E, Kahn JE, Lefevre G, Maurier F, Moulis G, Papo T, Dossier A, Descamps V, Salort-Campana E, Richard MA, Bergot E, Mortier L, Costedoat-Chalumeau N, Genot S, Perez F, Piette AM, Samson M, Schleinitz N, Zénone T, Lacoste M, de Boysson H, Madaule S, Rigolet A, Champtiaux N, Hervier B, Bouvier AM, Jooste V, Léonard-Louis S, Maisonobe T, Aouba A, Benveniste O, Bienvenu B, Allenbach Y; French Myositis Network. Systematic retrospective study of 64 patients with anti-Mi2 dermatomyositis: A classic skin rash with a necrotizing myositis and high risk of malignancy. J Am Acad Dermatol. 2020 Mar 31:S0190-9622(20)30480-1.
• Dieudonné Y, Allenbach Y, Benveniste O, Leonard-Louis S, Hervier B, Mariampillai K, Nespola B, Lannes B, Echaniz-Laguna A, Wendling D, Von Frenckell C, Poursac N, Mortier E, Lavigne C, Hinschberger O, Magnant J, Gottenberg JE, Geny B, Sibilia J, Meyer A. Granulomatosis-associated myositis: High prevalence of sporadic inclusion body myositis. Neurology. 2020 Mar 3;94(9):e910-e920.
• Duchesne M, Leonard-Louis S, Landon-Cardinal O, Anquetil C, Mariampillai K, Monzani Q, Benveniste O, Allenbach Y. Edematous myositis: a clinical presentation first suggesting dermatomyositis diagnosis. Brain Pathol. 2020 Sep;30(5):867-876.
• Langlois V, Gillibert A, Uzunhan Y, Chabi ML, Hachulla E, Landon-Cardinal O, Mariampillai K, Champtiaux N, Nunes H, Benveniste O, Hervier B. Rituximab and Cyclophosphamide in Antisynthetase Syndrome-related Interstitial Lung Disease: An Observational Retrospective Study. J Rheumatol. 2020 Nov 1;47(11):1678-1686.
• Mariampillai K, Granger B, Amelin D, Guiguet M, Hachulla E, Maurier F, Meyer A, Tohmé A, Charuel JL, Musset L, Allenbach Y, Benveniste O. Development of a New Classification System for Idiopathic Inflammatory Myopathies Based on Clinical Manifestations and Myositis-Specific Autoantibodies. JAMA Neurol. 2018 Dec 1;75(12):1528-1537. doi: 10.1001/jamaneurol.2018.2598
• Dzangué-Tchoupou G, Mariampillai K, Bolko L, Amelin D, Mauhin W, Corneau A, Blanc C, Allenbach Y, Benveniste O. CD8+T-bet+ cells as a predominant biomarker for inclusion body myositis. Autoimmun Rev. 2019 Apr;18(4):325-333. doi: 10.1016/j.autrev.2019.02.003. Epub 2019 Feb 28.
• Mauhin W, Mariampillai K, Allenbach Y, Charuel JL, Musset L, Benveniste O. Anti-mitochondrial antibodies are not a hallmark of severity in idiopathic inflammatory myopathies. Joint Bone Spine. 2018 May;85(3):375-376. doi: 10.1016/j.jbspin.2017.04.004. Epub 2017 Apr 20.
• Lilleker JB, Rietveld A, Pye SR, Mariampillai K, Benveniste O, Peeters MT, Miller JA, Hanna MG, Machado PM, Parton MJ, Gheorghe KR, Badrising UA, Lundberg IE, Sacconi S, Herbert MK, McHugh NJ, Lecky BR, Brierley C, Hilton-Jones D, Lamb JA, Roberts ME, Cooper RG, Saris CG, Pruijn GJ, Chinoy H, van Engelen BG; all UKMYONET contributors. Cytosolic 5′-nucleotidase 1A autoantibody profile and clinical characteristics in inclusion body myositis. Ann Rheum Dis. 2017 May;76(5):862-868. doi: 10.1136/annrheumdis-2016-210282. Epub 2017 Jan 25.
• Allenbach Y, Arouche-Delaperche L, Preusse C, Radbruch H, Butler-Browne G, Champtiaux N, Mariampillai K, Rigolet A, Hufnagl P, Zerbe N, Amelin D, Maisonobe T, Louis-Leonard S, Duyckaerts C, Eymard B, Goebel HH, Bergua C, Drouot L, Boyer O, Benveniste O, Stenzel W. Necrosis in anti-SRP+ and anti-HMGCR+myopathies: Role of autoantibodies and complement. Neurology. 2018 Feb 6;90(6):e507-e517. doi: 10.1212/WNL.0000000000004923. Epub 2018 Jan 12. PMID: 29330311
• Allenbach Y, Keraen J, Bouvier AM, Jooste V, Champtiaux N, Hervier B, Schoindre Y, Rigolet A, Gilardin L, Musset L, Charuel JL, Boyer O, Jouen F, Drouot L, Martinet J, Stojkovic T, Eymard B, Laforêt P, Behin A, Salort-Campana E, Fain O, Meyer A, Schleinitz N, Mariampillai K, Grados A, Benveniste O. High risk of cancer in autoimmune necrotizing myopathies: usefulness of myositis specific antibody. Brain. 2016 Aug;139(Pt 8):2131-5. doi: 10.1093/brain/aww054. Epub 2016 Apr 17.