Muscular channelopathies
RSS feedMuscle imaging can show lesions in periodic paralysis
Periodic paralysis (PP) is an ultra-rare muscle channelopathy characterized by episodes of transient, sometimes prolonged, motor deficits. British researchers conducted a muscle imaging study of the lower limbs of 45 patients diagnosed with PP: 17 patients had a mutation in a calcium channel gene, 16 in a sodium channel gene and 12 in a potassium … [Read more]
An ENMC workshop on anesthesia in NMD
No less than 28 researchers or clinicians (including three French) and two patient representatives from 15 countries participated in the 259th workshop of the European Neuromuscular Center (ENMC). They exchanged between December 2020 and May 2021 around three themes: anesthetic management in various neuromuscular diseases (myasthenia gravis, congenital muscular dystrophies, channelopathies, etc.), with a review … [Read more]
Post hoc analysis and case report support dichlorphenamide in muscle channelopathies
Dichlorphenamide (Keveyis®) is prescribed to prevent attacks of periodic hypokalaemic and hyperkalaemic paralysis, two muscular channelopathies. A post-hoc analysis of the results of the randomized double-blind placebo-controlled HYP-HOP trial and its open-label extension: confirms the efficacy of dichlorphenamide at a dose of 100 mg / day in these two indications, with a lasting reduction … [Read more]
