Job opportunities

Please find below vacancies available at the Institute of Myology.

 

Postdoctoral position in molecular mechanisms involved in SMA - Institute of Myology, Paris - 01/07/2021

The “Biotherapies for motor neuron disorders group” (BOND) is looking for a postdoctoral fellow to lead a research project on the understanding of novel molecular mechanisms involved in the Spinal Muscular Atrophy (SMA) pathogenesis. The project includes in vitro studies on mouse and human cell lines, analysis of human biopsies and in vivo tests on a mouse model of the disease. More details will be provided on demand.

The BOND group is located in the Center of Research in Myology, Sorbonne University, INSERM U974, Institute of Myology (Pitié-Salpêtrière hospital, Paris), a unique environment for research and development of innovative therapies for neuromuscular diseases. Candidates will therefore have the opportunity to work in a stimulating and enriching context.

The team is focused on the study of novel biotherapies for motor neuron disorders and contributed to seminal discoveries on gene therapy approaches for SMA (Besse A., Mol Ther, 2020; Dominguez A., Human Mol Genet, 2011). The current project in the lab is focused on the investigation of mechanisms altered in the disease and involved in the degeneration of motor neurons and muscle cells.

We are looking for a highly motivated and creative scientist with a strong background in molecular, cell or stem cell biology and in vivo manipulation skills. Experience in epigenetic and bioinformatics analyses are a plus. A good track-record of publications is required together with the ability to work in a collaborative environment.

 

The position is available for a scientist motivated by passion for science and projects at the interface between basic and applied research.
The working language will be English. The position is for 1 year, renewable.

 

Please send us your application with a CV, a cover letter outlining your motivation, a short summary of your past research and the names of at least two references.

 

Contact: p.smeriglio@institut-myologie.org

 

Access the complete announcement: Postdoctoral position in molecular mechanisms involved in SMA


Postdoctoral fellow in Gene therapy for ALS (M/F) - Institute of Myology, Paris - 01/07/2021

The “Biotherapies for motor neuron disorders group” (BOND) is looking for a postdoctoral fellow to lead a preclinical research project on the evaluation of the therapeutic effects of a gene therapy strategy for the treatment of Amyotrophic Lateral Sclerosis (ALS) caused by mutation of the SOD1 gene. The project includes in vitro studies on human cell lines and in vivo tests on a mouse model of the disease. More details will be provided on demand.

The BOND group is located in the Center of Research in Myology, Sorbonne University, INSERM U974, Institute of Myology (Pitié-Salpêtrière hospital, Paris), a unique environment for research and development of innovative therapies for neuromuscular diseases. Candidates will therefore have the opportunity to work in a stimulating and enriching context.

The team is focused on the study of novel biotherapies for motor neuron disorders. Specifically, we demonstrated the beneficial effect of an adeno-associated vector and an exon skipping strategy to reduce the production of toxic SOD1 in a murine model of the disease (Biferi et al., Mol Ther, 2017). This therapeutic product is currently being developed in collaboration with the Genethon (Evry, France).

In the frame of a pre-clinical study for our therapy, we are looking for a highly motivated scientist with a good background in cell biology, molecular biology and in vivo manipulation. Experience in AAV handling and computational biology would be an advantage. A track-record of publications in peer-reviewed journal and a good ability to work in a collaborative environment and to supervise students are required.

 

The position is available for a scientist motivated by projects at the interface between basic and applied research. The position is for 1 year.

 

Please send us your application with a CV, a cover letter outlining your motivation, a short summary of your past research and the names of at least two references.
The working language will be English.

 

Contacts: p.smeriglio@institut-myologie.org

 

Access the complete announcement: Postdoctoral fellow in Gene therapy for ALS (M/F)


Research Associate and Engineer (M/F) - Institute of Myology, Paris - Myology Centre for Research - 07/05/2021

A research associate (ingénieur de recherche) and an engineer (ingénieur d’étude) positions are available in the BOND group, at the Myology Center for Research, Sorbonne University, INSERM U974, Institute of Myology (Pitié-Salpêtrière hospital, Paris).

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder characterized by the progressive loss of motor neurons and voluntary muscle function and with no effective cure to date. Our laboratory is specialized in biotherapies for motor neuron disorders and demonstrated the effect of a gene therapy vector and an exon skipping strategy to reduce the production of toxic SOD1 in a murine model of the disease (Biferi et al., Mol Ther, 2017).

We are currently characterizing a novel AAV-based therapy for the most common genetic form of ALS caused by hexanucleotide repeats expansion in the C9orf72 gene. In collaboration with an industrial partner, the following positions will be available to study the therapeutic effects of our treatment in experimental models using lentiviral and adeno-associated viral vectors.

Candidates will be selected according to the following criteria:

Engineer: Master 2 and at least 3-year experience in a research laboratory;

Research Associate: PhD in Biology with 3-year experience in a research laboratory;

Strong experiences in cell biology, molecular biology and gene transfer using lentiviral vectors. Expertise in induced pluripotent stem cell (iPSC) manipulation is required. Background in pathophysiology of nucleotide repeat expansion diseases and genome instability will be an advantage.

To complete the project successfully, we are looking for highly motivated scientists with strong scientific background in biomedical sciences, good ability to work in a collaborative environment, knowledge of English and good communication skills. The candidates should be able to work independently, under the supervision of a researcher.

The Myology Centre for Research offers a unique environment for research and development of innovative therapies for neuromuscular diseases. Candidates will therefore have the opportunity to work in a stimulating and enriching context.

The positions are to be filled immediately and the salaries will be established based on the candidate’s experience.

The duration of the contracts is 24 months.

Candidates can send their CV, cover letter and contact information of two references to the following email addresses:
p.smeriglio@institut-myologie.org and m.cappella@institut-myologie.org

Access the complete announcement Research Associate and Engineer (M/F) 

 


Clinical Research Physician (M/F) - Institute of Myology, Paris - I-Motion Adults - 01/04/2021

Located in Paris in the heart of the largest European hospital, the Pitié-Salpêtrière, the Institute of Myology was created in 1996 by AFM-Téléthon, a patient’s organization. Its objective is to promote the recognition and development of myology as a standalone clinical and scientific discipline. The Institute of Myology coordinates, around the patient, medical care, basic research, applied research, clinical research and teaching. The Institute of Myology Association, an association under the law of 1901, was created in 2005 by the AFM-Téléthon as a support structure for this group.

The I-Motion Adults platform, located within the Institute of Myology and created in July 2019, is a clinical research platform dedicated to the implementation and conduct of clinical trials on neuromuscular diseases affecting adult patients. Located in the Pitié-Salpêtrière Hospital, the platform works in close collaboration with the Neuromyology Department, the Hospital’s Reference Center for Rare Neuromuscular Diseases and the I-Motion Pediatric platform at the Trousseau Hospital. There is also constant interaction with the research teams of the Research Center in Myology as well as with the various entities within the AFM-Téléthon galaxy (Généthon…).

The Institute of Myology is recruiting a Clinical Research Physician for the I-Motion Adults platform.

This position is to be filled on a full-time permanent contract and is based at the Institute of Myology (Hôpital Pitié-Salpêtrière, Paris 13)

 

Please send your application (CV + cover letter) by e-mail to the following address: recrutement-aim@institut-myologie.org

 

Access the complete announcement Clinical Research Physician (M/F)


Bio-informatic engineer - Projet manager (M/F) - Institute of Myology, Paris - 15/01/2021

Located in Paris at the heart of the largest European hospital, Pitié-Salpêtrière, the Institute of Myology was created in 1996 by AFM-Telethon, a patient’s organization. Its goal: Promote Myology and have it accepted as a standalone clinical and scientific discipline. The Institute of Myology coordinates around the patient, medical care, basic research, applied research, clinical research and teaching.

Main Purpose

The Strategic plan of the Institute of Myology has a specific objective focus on digitalization.

A digital task force, recently created, would like to address new unmet needs regarding data management, computerized science, data analytics and bioinformatics project to prepare a future Muscle hub and the Medical Artificial Intelligence projects focused on NeuroMuscular and rare diseases.

The project manager will have to support more than 15 teams (Myology research center, Imaging, evaluation, histopathology, Myobank, clinical trials, healthcare professionals in the service of Neuro-Myology…) that would like to synchronize decades of unharmonized data and write the future with standardization, compliance, interoperability and AI to share their expertise with colleagues, Academics, start-ups and other partners.

There is a possibility of evolution, creating a specific department as a data platform with a team after clarification of the overall project.

Role

This role will require an overarching view on all relevant activities and liaising closely with key stakeholders to ensure the needs and input of the strategic digital task-force as a coordinator a first point of contact and a comprehensive support service for partners, experts and the steering committee.

The project manager includes direct line management and development of the Strategic Director in the Coordination team.

This permanent contract, based at the Institute of Myology (Hôpital Pitié Salpêtrière, Paris 13), is to be filled on a full-time basis.

Thank you to send your application (CV + cover letter) by e-mail to the following address: recrutement-aim@institut-myologie.org

Access the complete announcement Bio-informatic engineer – Projet manager (M/F)