Please find below vacancies available at the Institute of Myology.
Senior Project Manager (m/f) - European Reference Network (ERN) EURO-NMD - Institute of Myology, Paris - France - 25/07/2022
European Reference Networks (ERNs) are networks involving centers of expertise and health care providers across Europe. They aim to tackle complex or rare diseases and conditions that require highly specialized treatment, as well as a concentration of knowledge and resources. Established in 2017 and co-funded by the European Commission, EURO-NMD is a European reference network for the thematic grouping of rare neuromuscular diseases (NMDs), a broad group of related disorders that represent a major cause of mortality and lifelong disability in children and adults.
The network brings together 84 highly specialized multidisciplinary healthcare providers (HCPs) from 25 EU Member States, as well as more than 23 European Patient Advocacy Groups (ePAGs). It is structured around five disease groups, four cross cutting diagnostic groups and there are also working groups dedicated to research, ethics, education and a patient advisory committee.
EURO-NMD is currently funded by the European Union’s EU4Health program initially for 18 months, but will be extended beyond 2023. The network also benefits from other funding schemes set up by Europe specifically for ERNs to develop certain activities, such as the Connecting Europe Facility (CEF Telecom eHealth) and the 3rd EU Health Programme. The EURO-NMD is also a partner in other EU-funded projects, in particular the ERICA consortium, in which all 24 ERNs participates, and the European Joint Programme on Rare Diseases (EJP RD).
The coordination of EURO-NMD is based in France, at the Institute of Myology located at the heart of the largest European hospital, the Pitié-Salpêtrière, which is part of the Assistance Publique – Hôpitaux de Paris (AP-HP). Currently, the coordination of the ERN is ensured by the AP-HP and operated by a team of 6 people: a coordinator, a clinical advisor, a project responsible, a project manager, a communication officer and a project assistant.
The purpose of the Senior Project Manager position is to accomplish the objectives defined in the EU grants of the EURO-NMD. This involves ensuring proper functioning, development and implementation of the network activities in cooperation with the ERN members.
He/she is supervised by the Project Responsible, he/she works with a project team and in connection with the European Commission, which provides the necessary means for the progress of the project.
Main tasks and responsibilities
- Ensure that the objectives of current (EU4Health Programme, 3rd EU Health Programme, CEF Telecom eHealth) and future projects related to the network are met.
- Provide project management support to the EURO-NMD Coordinator and the Project Responsible (budget, actions).
- Monitor contractual deadlines and contribute to the drafting of technical and financial deliverables and reports to ensure that deadlines for submission to the EU are met.
- Monitor the progress of the activities planned in the roadmap in connection with the other members of the project. Be a driving force in the use of new methods to advance the project
- Follow up the work of the working groups. Work alongside the Committees’ Chairs to prepare and facilitate meetings.
- Write agendas and minutes of meetings.
- Contribute to the strategic communication plan to disseminate project results and increase the network visibility.
- Establish working relationships with other ERNs and participate in inter-ERN activities.
- Ensure the proper flow of information among members, provide support and ensure follow-up of requests.
- Participate with the Project Responsible in the organization of meetings of the governance bodies of the EURO-NMD (Board of the Network, Executive Committee)
- Ensure the interface between the network and the European Commission.
- Participate in regular videoconferences of the working groups (Project managers, ITAG, monitoring, knowledge generation, etc.)
- Follow up the activities of related projects and networks: ERICA, EJP-RD, Solve-RD
- Ensure the traceability of decisions and the organization of shared documents.
- PhD in science or equivalent
- Significant experience in the management of European projects or equivalent
- Ability to work in a team, in a multicultural environment
- Fluent in English (oral and written) – working language of the network
- Excellent project management skills and ability to deliver results on time and on budget
- Organized and rigorous in order to establish priorities according to the requests
- Writing skills and ability to present information clearly and effectively
- Ability to search, analyze and synthesize information
- Negotiation skills
- Good interpersonal skills
- Responsive and adaptable
- Strong computer skills, working knowledge of Microsoft Office
- Experience and knowledge in the rare diseases field as well as in the neuromuscular field would be especially valuable
- Previous research experience would be a plus
- Good knowledge of relevant EU projects/initiatives in the area.
- English environment (working language of the network)
- Requires travelling in the EU (occasionally) Remote work possible (2 days/week)
- Fixed-term contractual position attached to the Clinical Research and Innovation Delegation (DRCI) of the AP-HP
- Working hours: 100%.
- Salary according to experience, diploma and APHP’s salary grid.
Please send your application (CV + cover letter) by e-mail to the following address:
Desired starting date: 01/10/2022
Download job description Senior Project Manager (M/F) – European Reference Network (ERN) EURO-NMD
Clinical Research Associate - I-Motion - Institute of Myology, Paris - France - 13/07/2022 (in French)
Situé à Paris au cœur du plus grand centre hospitalier européen, l’hôpital de la Pitié-Salpêtrière, l’Institut de Myologie est né en 1996 sous l’impulsion d’une association de malades et parents de malades, l’AFM-Téléthon. Son objectif : favoriser l’existence, la reconnaissance et l’essor de la myologie en tant que discipline clinique et scientifique à part entière. L’Institut de Myologie coordonne, autour du malade, la prise en charge médicale, la recherche fondamentale, la recherche appliquée, la recherche clinique et l’enseignement. Demain, la création de la Fondation de Myologie permettra de pérenniser et élargir les actions de l’Institut de Myologie.
Contexte et Finalité
Les études cliniques sont au cœur de l’activité de l’Institut de Myologie qui comprend deux plateformes d’essais cliniques pour les maladies neuromusculaires, I-Motion pédiatrique (située sur le site de l’hôpital Trousseau) et I-Motion adultes (située sur le site de l’hôpital Pitié-Salpêtrière).
L’Association Institut de Myologie, recrute un(e) Attaché(e) de Recherche Clinique (ARC) pour assurer la mise en place et le suivi des essais cliniques en étroite collaboration avec le personnel médical et paramédical.
Sous la supervision de son N+1, en collaboration avec les investigateurs et les différents intervenants académiques et industriels, vous aurez pour mission la mise en place et le suivi des essais cliniques adultes et pédiatriques en garantissant la qualité des données recueillies et le respect de la règlementation.
Vos principales responsabilités sont notamment :
- Recueillir et rédiger les documents indispensables pour assurer la conformité technique (plaquette d’étude, worksheet, procédures) et règlementaire des essais cliniques.
- Assurer le fonctionnement de la logistique nécessaire au déroulement des essais cliniques (planning des patients et des intervenants, suivi des prélèvements et des unités de traitements si applicable…).
- Contrôler le déroulement des essais selon les textes en vigueur, les bonnes pratiques cliniques et les
procédures opératoires standards.
- Proposer des améliorations, des adaptations si nécessaires des procédures opératoires.
- Vérifier et garantir la qualité des données, et organiser des visites sur sites et des réunions de travail
avec les interlocuteurs internes et externes (visites de mise en place, monitoring, clôture, réunion
- Déplacement possibles à l’échelle nationale ou internationale.
- Rapport d’activités réguliers avec l’équipe projet.
- De formation Bac+ 4 complétée par une formation d’Attaché de recherche clinique
- Expérience dans le domaine de la recherche clinique sur un poste équivalent souhaitée
- Aisance relationnelle
- Bonne maîtrise de la langue anglaise
- Bonne maîtrise du Pack Office et des bases de données
Nature du poste : CDD 12 mois à temps plein (35h)
Merci d’adresser par mail votre dossier de candidature (CV + lettre de motivation) à l’adresse suivant : email@example.com
Télécharger l’annonce du poste d’Attaché(e) de Recherche Clinique pour la structure dédiée aux Essais Cliniques (I-Motion)
Post-doctoral fellowship in muscle cell biology - Myology Centre For Research, Institute of Myology, Paris - France - 30/05/2022
We are looking for a highly motivated and creative muscle cell biologist to join our lab. The post- doctoral fellowship position is funded by an EQUIPE FRM grant and is open with a flexible starting date until September 2022.
The project aims at studying cell communication during human skeletal muscle regeneration in aging and pathological conditions. Muscle releases ‘myokines’, especially during the early stages of differentiation, which corresponds to the early stage of muscle regeneration. Tissue repair involves many cell types: inflammatory, interstitial, or even fibrotic in pathological situation. The complex orchestration of muscle regeneration necessitates a well-defined set of secreted molecules allowing cell-cell communication and therefore co-regulation. Muscle regeneration is less efficient in the elderly after falls or surgery, while we have previously shown that muscle stem cells have a good potential for proliferation and differentiation. In addition, it has been shown that the muscle secretome can be disturbed in several pathological situations. This project investigates the secretome of adult muscle cells across control, aged and pathological subjects and the impact of these secreted molecules on muscle regeneration. Secretome of muscle cells have already been performed and the post-doctoral research fellow will perform functional follow-up experiments to assess the impact of selected myokines on muscle regeneration. Using innovative approaches with co-culture systems and a xenograft model, the project will deliver novel mechanistic insights into how the kinetics of muscle regeneration is deregulated by secreted molecules during aging and in pathologies, and how these can be proposed as therapeutic targets to promote muscle health.
Our lab is located at the Myology Research Center within the Institute of Myology in Paris. Our Lab’s main interests are at the crossroad between fundamental muscle cell biology, muscle aging and therapeutic strategies for muscle disease. The Center and the closely situated Sorbonne University and Pitié-Salpêtrière Hospital offer a dynamic environment with state-of-the art facilities and platforms.
The candidate should have a PhD in Life Science and an interest in studying muscle regeneration. Preference will be given to those with a PhD degree and a first post-doctoral experience. Prior experience in muscle physiology, molecular biology, cell communication and cell signaling is preferred; experiences in primary cell culture, and omics analysis are preferred but not mandatory. Necessary skills include creativity, good oral and written communication skills in English. A good capacity to work in a collaborative environment is required.
Please submit curriculum vitae, statement of research interest and names/address of two references to Capucine Trollet firstname.lastname@example.org
Download the full job description Post-doctoral research fellow in muscle cell biology
Post-doctoral position in Physiology and Cell Biology - Myology Centre for Research, Institute of Myology, Paris - France - 24/05/2022
A two-year fully funded post-doctoral fellowship position sponsored by ANR will be available at the Myology Research Center in the group of Stéphane Vassilopoulos to assess the structure/function relationship of clathrin structures in mechanotransduction and endocytosis. The main objective is to reveal the mechanisms by which muscle cells form clathrin plaques using alternative splicing isoforms of the endocytosis machinery and provide novel insight to myo- tonic dystrophy pathophysiology, a “spliceopathy” affecting in particular muscle and central nervous system functions.
The Myology Research Center is a multidisciplinary research center dedicated to research on muscle and its pathologies. Located in the heart of the Groupe Hospitalier Pitié-Salpêtrière and the Faculté de Médecine Sorbonne Université in Paris, the Research Center benefits from a privileged scientific and medical environment. The position will be in the ‘Muscle cell organization and therapy of dominant centronuclear myopathy’ team lead by Marc Bitoun, whose main interests are at the crossroads between fundamental cell biology of membrane trafficking and therapeutic strategies for centronuclear myopathy
- We are looking for a highly motivated, enthusiastic and interactive candidate with a Ph.D degree, who is interested in applying his/her knowledge in molecular and cellular biology and mouse physiology.
- Preference will be given to those with a recent PhD degree and a good publication record.
- Prior experience in mouse experimentation is required; experiences in primary cell culture and mouse models are preferred but not mandatory.
- Necessary skills include creativity, good oral and written communication abilities in English.
- A good ability to work in a collaborative environment is required.
Please send a cover letter stating your previous research experience and motivation, CV and contact information for two references as a single file to: email@example.com.
Deadline to apply: 2022, September 1st.
Download the full position description Post-doctoral position in Physiology and Cell Biology
Histopathology platform manager - Genethon, Institute of Myology, Paris - France - 19/05/2022
Genethon, a leader in the development of innovative therapies, in particular gene therapy for rare diseases, is a structure that integrates research, preclinical and clinical development.
The Institute of Myology, an international reference centre, coordinates medical care, research, clinical development and teaching around the patient. The Institute of Myology participates in numerous trials and clinical studies mainly concerning neuromuscular diseases but also muscle injuries related to high-level sport or ageing.
Genethon and the Institute of Myology are creating a collaborative partnership to offer high quality expertise and services for translational research, diagnostics and therapeutic projects developed by both organisations.
We are recruiting a Histopathology platform manager (M/F) on a part-time basis (50% at Genethon; 50% at the Institute of Myology)
- You will manage the activity and teams of the Histopathology platforms, analyse the results produced and manage partners and subcontractors.
- You will read and interpret slides and provide your expertise to researchers and to inform decision-making in development projects.
- You will manage the implementation of a quality reference system and a validation system for histological methods.
- You will also develop the digitalisation of the activity
- In collaboration with the platform’s anatomopathologist, you will identify and implement technical developments and new histological markings in line with the needs of research teams, therapeutic projects and diagnostics (automation, use of artificial intelligence, etc.).
- You will pass on your knowledge and know-how internally. You will be responsible for monitoring technological and scientific developments in the field.
- You have a PhD in science with at least 6 years experience as a researcher and/or manager of a technology group or platform, with strong skills in histological sample collection and processing techniques, staining, immunohistological labeling, light and fluorescence microscopy and image analysis. You are good at innovation.
- You have a successful track record in management and organisation (quality; digitalisation of tools, …). You listen to your team as well as to your internal clients.
- You have strong interpersonal skills, good oral and written communication skills, the ability to work transversally with experts from various backgrounds, and you speak English fluently.
This is a permanent position, shared between the Institute of Myology – Paris – and Evry (91).
To apply, please send your application on our website: https://genethon-recrute.talent-soft.com
Download the full job description (in French): Histopathology platform manager