A Japanese team of neurologists and nephrologists report the observation of a 61-year-old patient diagnosed with autoimmune necrotising myopathy:
- the clinical history and the positivity of anti-SRP autoantibodies were consistent with this diagnosis,
- treatment consisted of corticosteroids and immunoglobulins, followed by tacrolimus,
- eight weeks after initiation of this treatment, thrombotic microangiopathy was observed and confirmed by renal biopsy, necessitating haemodialysis.
The authors point to the responsibility of anti-SRP autoantibodies rather than iatrogenesis.
