The role of intestinal flora is the subject of sustained attention in medical research, particularly in dysimmune diseases such as myasthenia gravis. Various publications point to the existence of dysbiosis in this disease:
- The results of the German Mybiom study show, in cases of myasthenia (n=42), a lower diversity of intestinal flora than in a healthy control group (n=12), and a significant increase in the abundance of delta proteobacteria and Faecalibacterium (even in the absence of corticosteroid therapy) compared with patients suffering from non-inflammatory neurological diseases (n=18).
- A study conducted in China found dysbiosis of the intestinal microbiota pre-existing treatment in 11 adults with newly diagnosed myasthenia, compared with a control group.
- Another study conducted in China, this time involving 53 children with myasthenia and 46 healthy children, found significant differences in the abundance of certain bacterial species, the presence of human adenoviruses only in 10 children with myasthenia, and a reduction in the production of short-chain fatty acids by the intestinal microbiota and in serum butyrate levels in the myasthenia group (with or without anti-RACh).
