Turkish clinicians report their experience with a 12-year-old patient suffering from autoimmune myasthenia who developed skin intolerance (appearance of urticarial plaques) after each oral administration of pyridostigmine.
- An initial study had revealed hypersensitivity to the product, even when the doses were split,
- a desensitisation protocol was then carried out with prior premedication with a cocktail combining pheniramine, methylprednisolone and ranitidine,
- pyridostigmine was then administered, starting at 1/100 of the target dose and tripling the dose every 30 minutes to reach 60 mg in 120 minutes.
This protocol enabled the patient to tolerate her pyridostigmine treatment perfectly and for a long time.
