A review of the literature has enabled Chinese clinicians to carry out a meta-analysis of data from 1,109 patients with juvenile myasthenia published in 11 articles between 2000 and 2022.
- The disease appeared at an average age of 7.38 years (from one to 18 years), in the form of ocular involvement (ptosis, diplopia, strabismus) in 60.6% of cases, and generalised myasthenia gravis in 39.4%.
- Almost 80% were positive for anti-RAch antibodies.
- Of the 641 children who underwent thymic histology, almost 65% showed thymus hyperplasia, while 2.2% had a thymoma.
- The first-line treatment was pyridostigmine in 97.8% of cases and corticosteroids in 68.6%.
- Six children recovered spontaneously without treatment.
- Thymectomy was performed in just over 45% of cases.
- Complete and stable remission was achieved in 23.7% of cases, and there were 8 deaths in all.
