To address the lack of data on the course of scoliosis without treatment that could be used as a benchmark for clinical trials or modifying treatment, an Italian team conducted a retrospective study in 84 people with SMA type II.
- The mean scoliosis angle was 46°, with those aged seven years or less being significantly lower than those aged eight years or more.
- There was also a correlation between Cobb angle and motor function, with the former being higher in children with lower Hammersmith motor scale scores.
- The mean annual progression of scoliosis was 5.63°.
