Longitudinal cardio-MRI follow-up shows early myocardial damage in DMD

Duchenne muscular dystrophy (DMD) is invariably accompanied by cardiomyopathy, the most frequent cause of death. An American team looked at the kinetics of cardiac involvement by longitudinally analysing cardio-MRI images of 59 children with DMD with a median age of 5.6 years. Compared to images from a control group of healthy subjects, it appears that :

  • the high resolution of the 3 Tesla machines allows the visualisation of subclinical lesions very early in the growth of the children;
  • the composite circumferential tension index used for the study was more often deteriorated in the lower part of the myocardium;
  • this imaging deterioration precedes the appearance of signs of left ventricular dysfunction by several years.


Longitudinal changes in cardiac function in Duchenne muscular dystrophy population as measured by magnetic resonance imaging. Batra A, Barnard AM, Lott DJ et al. BMC Cardiovasc Disord. 2022 Jun 9;22(1):260.