An inconclusive randomised trial of air-stacking in DMD

Canadian researchers have conducted a randomised trial in 70 patients with Duchenne muscular dystrophy (DMD) to determine the value of the air-stacking technique in interventional practice. This consists of recruiting, by means of an Ambu® for example, additional ventilatory territories with a view to better oxygenation:

  • of the 66 patients who continued the trial to its end (two years), 36 benefited from this technique twice a day in addition to the usual respiratory management,
  • the study of the ventilatory parameters (evolution of the vital capacity, peak-flow) did not show any significant difference between the treated and untreated groups.

However useful it may be, particularly for de-cluttering, this technique does not seem to be able to prevent the deterioration of vital capacity observed in DMD.

 

Routine lung volume recruitment in boys with Duchenne muscular dystrophy: a randomised clinical trial. Katz SL, Mah JK, McMillan HJ et al. Thorax. 2022 Mar 2:thoraxjnl-2021-218196.