Plasma biomarkers in myositis ossificans

Myositis ossificans or fibrodysplasia ossificans progressive (FOP) is an ultra-rare genetic disease associating progressive ankylosis and malformative bone abnormalities. American researchers have identified several biomarkers of the disease from the study of the plasma of 40 patients carrying the most frequently encountered mutation (R206H) and 40 control subjects:

  • adiponectin and tenascin levels were highly correlated with FOP genotype,
  • adiponectin is physiologically involved in hypoxia, inflammation and heterotopic ossification,
  • the kallikrein-7 level was associated with inflammatory flare-ups of the disease,

These data confirm the involvement of an iterative inflammatory process occurring on a determined genetic background.


Plasma-Soluble Biomarkers for Fibrodysplasia Ossificans Progressiva (FOP) Reflect Acute and Chronic Inflammatory States. Pignolo RJ, McCarrick-Walmsley R, Wang H, et al. J Bone Miner Res. 2021 Dec 26. B_Référence