Idiopathic inflammatory myopathies: links between interstitial lung disease and myositis-specific autoantibodies

One of the most common extramuscular manifestations of idiopathic inflammatory myopathies is interstitial lung disease. In addition, the diagnosis of IMI includes the search for myositis-specific autoantibodies. 

In this study, a team of French researchers and clinicians involving experts from the institute, included 257 patients with idiopathic inflammatory myopathies followed between 2003 and 2019. After re-evaluation of all chest scans and re-examination of results of CT scan, the authors showed that the interstitial lung disease in these patients could be classified into three groups according to CT scan criteria, and that these groups were significantly associated with myositis-specific autoantibodies.

 

Idiopathic inflammatory myopathies: CT characteristics of interstitial lung disease and their association(s) with myositis-specific autoantibodies. Laporte A, Mariampillai K, Allenbach Y, Pasi N, Donciu V, Toledano D, Granger B, Benveniste O, Grenier PA, Boussouar S. Eur Radiol. 2022 Jan 13. doi: 10.1007/s00330-021-08411-w. Online ahead of print. PMID: 35022809