Sexual dysfunction more common in myasthenia gravis

Sexual dysfunction includes problems related to sexual activity: libido, stimulation, painful intercourse, reduced satisfaction and orgasmic disorders, etc.

A Chinese observational study evaluated the frequency of these disorders in 319 participants, including 158 patients with myasthenia gravis (52 males and 106 females), and 161 unaffected controls, mean age 41.82 ± 10.44 years. The participants were asked to complete questionnaires, on a single occasion, to evaluate the presence of different types of sexual dysfunction and to measure anxiety and depression.


More sexual disorders reported

  • This affected 48.11% of female participants with myasthenia gravis, vs. 22.64% of unaffected females. These disorders are evidenced by a decline in overall sexual function, particularly reduced libido, sexual stimulation, lubrication and orgasm.
  • More than 40% of male participants with myasthenia presented erection disorders, and nearly 20% experienced premature ejaculation (vs. 8% of unaffected males).
  • The severity of the disorders is independent of disease severity;
  • Age and depression lead to an increase in sexual dysfunction (a correlation is also observed in the general population): reduced libido and lubrication, orgasmic disorders, together with lower sexual satisfaction scores are observed.

A long-term study would allow the onset and progression of these disorders to be monitored over time.


Sexual dysfunction in patients with myasthenia gravis. Jiancheng Wang, Chao Yan, Zhengyang Zhao, Hongxi Chen, Ziyan Shi, Qin Du, Ying Zhang, Yuhan Qiu, Yanling Lang, Lingyao Kong, Linjun Cai, Hongyu Zhou. J Neuroimmunol. 2021 Sep 15