Synaptic mechanisms of neurodegeneration and neuroprotection in Amyotrophic Lateral Sclerosis
Tuesday 25 February 2020 – 12:00-13:30
Francesco Roselli, MD, PhD (Dept. of Neurology, Ulm University, and German Center for Neurodegenerative Diseases (DZNE)-Ulm, Germany)
Hosted by : Maria-Grazia Biferi
Institute of Myology auditorium
Hôpital de la Pitié-Salpêtrière
Entrance 82 bd Vincent Auriol
In vivo electrophysiology and multiplexed chemogenetics demonstrate that, rather than hyperexcitation, ALS MNs experience postsynaptic disruptions and decreased synaptic responses. Synaptic restoration by cAMP/PKA improves disease pathobiochemistry stimulating MN firing, supporting a synaptic failure model for ALS.