Synaptic mechanisms of neurodegeneration and neuroprotection in Amyotrophic Lateral Sclerosis
Tuesday 25 February 2020 – 12:00-13:30
Francesco Roselli, MD, PhD (Dept. of Neurology, Ulm University, and German Center for Neurodegenerative Diseases (DZNE)-Ulm, Germany)
Hosted by : Maria-Grazia Biferi
Institute of Myology auditorium
Hôpital de la Pitié-Salpêtrière
Building Babinski
Entrance 82 bd Vincent Auriol
metro Chevaleret
In vivo electrophysiology and multiplexed chemogenetics demonstrate that, rather than hyperexcitation, ALS MNs experience postsynaptic disruptions and decreased synaptic responses. Synaptic restoration by cAMP/PKA improves disease pathobiochemistry stimulating MN firing, supporting a synaptic failure model for ALS.
