Oculopharyngeal muscular dystrophy
RSS feedMuscle imaging as an assessment methodology in OPMD
Canadian researchers have developed a whole-body magnetic resonance imaging protocol to aid diagnosis and study the natural history of the disease in ten patients with oculopharyngeal muscular dystrophy (OPMD): data obtained by quantitative and semi-quantitative methods were compared with those of ten patients with other muscular dystrophies and five subjects without the disease, the degree … [Read more]
The surgical treatment of myopathic ptosis remains complex
Many neuromuscular diseases are accompanied by ptosis of myopathic origin. The main mechanism is a deficit of the eyelid levator muscle. American ophthalmologists conducted a review of the literature on the surgical treatment of this complication: 27 articles, each with at least four original cases, came to their attention, CPEO (chronic progressive external ophthalmoplegia), oculopharyngeal … [Read more]
Characterisation of PABPN1 aggregates in OPMD – Interview with Capucine Trollet
The results of an international study conducted by the Institute’s Capucine Trollet and Vincent Mouly team have just been published in Acta Neuropathologica. The article relates to the characterisation of PABPN1 aggregates performed on a unique series of 90 muscle biopsies from OPMD patients, collected from clinicians in France, Canada, the Netherlands and Israel, and on … [Read more]
Endothelin: a new player in muscle fibrosis – Interview with Capucine Trollet
Mona Bensalah completed her thesis under the supervision of Elisa Negroni and Vincent Mouly in the team “Cellular and molecular orchestration in muscle regeneration, during aging and in pathologies” directed by Capucine Trollet and Vincent Mouly, at the Institute’s Myology Research Centre. Her work, completed by that of Laura Muraine, has just been published in … [Read more]
