Blog Archives
Pyridostigmine tends to improve subjective fatigability, but shows no significant effect on muscle strength
The SPACE clinical trial took place between 2016 and 2017 in the Netherlands. This single-centre, phase II, cross-over trial evaluated an 8-week course of pyridostigmine versus placebo in 35 people with SMA types II to IV. The results, published in December 2022, show: no statistically significant difference in Nine-hole peg test (NHPT) and motor function … [Read more]
Researchers from the Institute’s NMR laboratory at the SFRMBM 2023 conference
The 6th conference of the French Society of Magnetic Resonance in Biology and Medicine (SFRMBM) was held in Paris from 27 to 29 March 2023. Its objective: to present the latest methodological advances and innovative applications in magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). The communications focused on developments in physics and technology … [Read more]
Cross-sectional study of neuromuscular fatigue in autoimmune myasthenia – Interview with Simone Birnbaum
Simone Birnbaum, a researcher at the Neuromuscular Physiology and Evaluation Laboratory directed by Jean-Yves Hogrel (NIC, Institute of Myology) has just published an article assessing neuromuscular fatigue in persons with Myasthenia gravis in the journal Clinical Neurophysiology. Interview with Simone Birnbaum. What was the aim of the study? Myasthenia gravis (MG) is a rare disease characterized by … [Read more]
A new pathophysiological mechanism to explain asymmetry in mitochondrial myopathies
Mitochondrial diseases are a heterogeneous group of disorders caused by alterations in mitochondrial DNA (missense mutations, sporadic large-scale deletions or mutations in nuclear maintenance genes). In these rare and complex diseases, symptoms can vary from person to person and between different tissues in a individual. More than 350 genes have been identified. A team of … [Read more]
Fiorella Grandi, winner of the prestigious Marie Sklodowska-Curie 2022 postdoctoral fellowship – Interview with F. Grandi and P. Smeriglio
Fiorella Grandi started a postdoctoral fellowship in October 2022 in the Epigenetics and biotherapies for motor neuron disorders (ALS & SMA) group led by Piera Smeriglio. She is a laureate of the MSCA Postdoctoral Fellowships 2022 call (Marie Skłodowska-Curie Actions – Horizon Europe). Her project* focuses on the epigenetic mechanisms** that influence the efficacy of … [Read more]
New long-term results of Zolgensma
In a press release dated 20 March 2023, Novartis presents new results for Zolgensma (onasemnogene abeparvovec) from two 15-year follow-up studies: Study LT 001 is conducted in 10 participants of the START trial who had been treated post-symptomatically with intravenous therapy before the age of 6 months: all are alive, able to feed orally and … [Read more]
Quantitative MRI to assess the evolution of muscle condition
Clinical trials related to dystrophinopathies are increasingly using quantitative MRI to assess the evolution of muscle status in patients with these neuromuscular diseases. In this prospective study, researchers from the NMR laboratory (NIC, Institute of Myology) and a clinician (Reference Centre for MNM Paris-Est, Institute of Myology) aimed to establish the sensitivity of the quantification … [Read more]
The European Reference Network (ERN) EURO-NMD is looking for a Project Assistant (M/F)
ERN EURO-NMD European Reference Networks (ERNs) are networks involving centers of expertise and health care providers across Europe. They aim to tackle complex or rare diseases and conditions that require highly specialized treatment, as well as a concentration of knowledge and resources. Established in 2017 and co-funded by the European Commission, EURO-NMD is a European … [Read more]
5th Neuromuscular Translational Summer School – 10-14 July 2023 – Leiden, The Netherlands
Organized by Euro-NMD and TREAT-NMD networks, this summer school offers lectures concerning the management of acquired and genetic neuromuscular diseases, the different steps of drug development, assessment tools, communication and the role of the patients in each of these steps. It will take place on 10-14 July 2023 in Leiden, The Netherlands. Registration … [Read more]
A look back at the 27th SFNP meeting
The 27th meeting of the Société Francophone du Nerf Périphérique (SFNP) took place on 10 & 11 March 2023 in Paris Bercy in the salons of the Aveyron. They are organised this year in collaboration with the Société Francophone d’Electroneuromyographie (SFENMG). The days are intended for health professionals, clinicians and researchers on transversal themes from … [Read more]
