The MG-ADL scale is not the most appropriate tool for assessing respiratory impairment in myasthenia gravis

Danish and French clinicians investigated the diagnostic and predictive value of the Myasthenia Gravis Activities of Daily Living (MG-ADL) scale for respiratory function in patients with myasthenia gravis:

  • 70 adults with a confirmed diagnosis of myasthenia gravis took part in the study, which involved completing three functional scales (the MGC, the QMG, and the MG-ADL) and undergoing spirometry at the same time;
  • 25 of the 70 were retested three years later,
  • there was a very poor correlation between the spirometry results and the respiratory symptoms as described and incorporated in the MG-ADL.

The authors emphasise the need to rely more on spirometry than on functional scales such as the MG-ADL, which is considered more subjective.

 

Assessing respiratory status in myasthenia gravis: limited value of the MG-ADL as a standalone tool compared with spirometry in a Danish cohort. Andersen LK, Birnbaum S, Missel M et al. J Neurol. 2026 Mar 24;273(4):231.