Japanese researchers have studied data from 154 patients diagnosed with dermatomyositis (DM), with the presence of autoantibodies directed against the MDA5 (menaloma differentiation-associated gene) antigen:
- in these forms, muscular involvement is generally modest, unlike interstitial lung disease, which often takes center stage,
- mortality is particularly high in the medium term (26% of cases studied),
- although the risk of relapse is not negligible, the longer-term prognosis is much better, and the administration of a JAK inhibitor can help overcome forms resistant to conventional treatment.
