French study highlights neurotoxicity of immune checkpoint inhibitors

Clinicians and researchers belonging to two oncology networks, including one devoted to paraneoplastic syndromes, have studied neurological complications arising during the use of a new class of drugs, immune checkpoint inhibitors:

  • 147 patients were included in the study, reflecting the significant frequency of the phenomenon;
  • complications of the peripheral nervous system were more frequent than those of the central nervous system, the combination of the two being much rarer;
  • the presence of associated myositis or neuromuscular junction damage, as well as the patient’s relatively young age, would appear to be factors with a better prognosis.

 

Neurological outcomes in immune checkpoint inhibitor-related neurotoxicity. Farina A, Birzu C, Elsensohn MH. et al. Brain Commun. 2023 May 27; 5(3): fcad169.