The French Cannemuss study confirms the efficacy of anti-Covid-19 messenger RNA vaccines in cases of amyotrophy

As the Covid-19 booster vaccination campaign gets underway in France, a new publication of the results of the Cannemuss observational study (supported by the AFM-Téléthon and carried out by Bordeaux University Hospital) shows that :

  • 90.1% of the 33 participants suffering from various neuromuscular diseases that had induced severe muscular atrophy had a serum level of anti-S antibodies considered to be protective, with strong neutralising activity, six weeks after two doses of a messenger RNA anti-Covid-19 vaccine,
  • 36.3% of participants retained high levels of anti-S at week 24,
  • of the remaining patients, 22 received a single booster vaccination, which restored high levels of anti-S and significant neutralising activity, benefits that were still present 29 weeks after the injection.

None of the participants developed symptomatic Covid-19 during the year of the study. Three of them reported an asymptomatic form.

 

Anti-SARS-CoV-2 (COVID-19) vaccination efficacy in patients with severe neuromuscular diseases. Damour A, Delalande P, Cordelières F et al. Rev Neurol (Paris). 2023 Aug 24:S0035-3787(23)00977-3.