Clinical biomarkers of gait quality and fall risk in late-onset Pompe disease

Compared with 20 healthy controls, the gait pattern and locomotion performance of 18 people with late-onset Pompe disease were found to be significantly impaired.

• Hip abductor strength is the main determinant of locomotor performance, gait stability and pelvic stability.
• Hip flexor strength is critical for knee and hip kinetics during gait.
• The duration of unipodal support is the main determinant of falls.

 

Determinants and Characterization of Locomotion in Adults with Late-Onset Pompe Disease: New Clinical Biomarkers.Maulet T, Cattagni T, Dubois F et al. J Neuromuscul Dis. 2023 Aug 4.