An international consortium of researchers coordinated by a Latvian team has studied the relevance of dosing neurofilaments in the blood of patients with Charcot-Marie-Tooth (CMT) disease:
- one hundred and one CMT patients and 64 healthy subjects were included in the study;
- of these, 73 patients and 28 controls were evaluated at least twice, three years apart;
- neurofilaments were measured in plasma and showed higher concentrations in the CMT group;
- however, no correlation could be established between the functional severity score of the disease and this rate.
The authors consider the predictive value of such an assay in this disease to be very low.
