Standards now available for muscle fibre size and type during growth

The evolution of muscle fibre morphometry during growth is poorly understood. French researchers and engineers involving scientists from the Institute of Myology have used a new image analysis algorithm (Carpaccio.Cloud) to better measure the evolution of several quantitative parameters over time:

  • 482 images, corresponding to 83 biopsied deltoid muscles and representing a total of 33,094 muscle fibres, were analysed.
  • Gender and pubertal period significantly influence the parameters of size and distribution of fibres between the different types.

Researchers and clinicians now have age-appropriate standards for interpreting muscle biopsies, whether for diagnosis or therapeutic trials.

 

Comprehensive morphometric assessment of deltoid muscle development in children: A cross-sectional study. Evangelista T, Kandji M, Lacene E et al. EBioMedicine. 2022 Dec;86:104367.