McArdle: clinical trial proves benefits of exercise

  • A clinical trial of 17 people with McArdle’s disease demonstrated the potential benefits of a 2-year training program targeting endurance and strength.
  • Six of the 10 patients who completed the program became asymptomatic, while the others experienced an improvement in their symptoms. In the control group without exercise, the disease remained stable at best.
  • Another study of 8 people with McArdle’s disease refutes the benefits on exercise tolerance of drinking a ketone-rich drink before exercise.


Long-term Exercise Intervention in Patients with McArdle Disease: Clinical and Aerobic Fitness Benefits. Alfredo Santalla A et al. Med Sci Sports Exerc. 2022 Mar


No effect of oral ketone ester supplementation on exercise capacity in patients with McArdle disease and healthy controls: A randomized placebo-controlled cross-over study. Nicoline Løkken N et al. J Inherit Metab Dis. 2022 Fév.