An experimental neuropsychological test for DMD

Based on previous work with mdx mice, the model animal for Duchenne muscular dystrophy (DMD), British researchers have developed a test for humans based on the startle response to several stimuli:

  • 11 children aged between 7 and 12 years with DMD and 9 healthy volunteers participated in the validation study,
  • The test included two types of stimuli, one called “threat” and the other “safe”, and a measurement of skin conductance and heart rate to assess the level of stress,

This test, whose interest and validation are confirmed here, could be added to the battery of neuropsychological tests used in clinical practice.


Development of a novel startle response task in Duchenne muscular dystrophy. Maresh K, Papageorgiou A, Ridout D, et al. PLoS One. 2022 Apr. 17(4):e0264091.