Farnesol is effective in laboratory models of CMT1A

• Korean researchers studied the effects of farnesol in Charcot-Marie-Tooth disease type 1A (CMT1A):

• They showed that the molecule enhances myelination of axons by Schwann cells:

• in a cellular model of CMT1A, it promotes the expression of myelin genes.
• in a mouse model of CMT1A, it increases the number and diameter of myelinated axons as well as nerve conduction velocities and improves motor skills in treated mice.

 

Farnesol Ameliorates Demyelinating Phenotype in a Cellular and Animal Model of Charcot-Marie-Tooth Disease Type 1A. Park NY, Kwak G, Doo HM et al. Curr Issues Mol Biol. 2021 Nov