Correlations between histology and immunological signature in dermatomyositis

The classification of dermatomyositis (DM) has undergone profound changes since the identification of myositis-specific autoantibodies (MSA). Tokyo neuromuscular pathology specialists re-evaluated 256 muscle biopsies from patients with DM trying to establish correlations between histological lesions and immunological signatures:

  • the positivity of the MxA staining, whether or not observed in the perivascular areas, was the main criterion for inclusion in the study,
  • at the end of the screening by MSA, only seven cases of DM remained seronegative,
  • correlations between histological lesions and MSA positivity have been established for most DM subtypes.


Muscle Pathology According to Antibody Subtypes. Tanboon J, Inoue M, Saito Y, et al. Neurology. 2021 Dec 6:10.1212/WNL.0000000000013176.