A more severe subtype of antisynthetase syndrome

Antisynthetase syndrome is part of the inflammatory myopathies (or myositis) known as “overlapping”. Chinese clinicians retrospectively studied a cohort of 113 adults with this form of myositis but free from any neoplastic process and rheumatic disease.

  • 25 of them had flare-ups or inflammation more frequently, on average 1.12 times per year;
  • this subgroup was at higher risk of developing rapidly progressive Interstitial Lung Disease (ILD);
  • patients with anti-PL7 antibodies were over-represented.

 

Description and Analysis of a Novel Subtype of the Anti-Synthetase Syndrome Characterized by Frequent Attacks of Fever and Systemic Inflammation in a Single-Center Cohort Study. Sun S, Chen Z, Zhang D, et al. Front Immunol. 2021 Sep 23;12:729602.