Fatigue and sedentary lifestyle go hand in hand in myasthenia gravis

Patients with myasthenia gravis often complain of a feeling of fatigue, sometimes severe and resistant at rest. 

A study based on self-administered questionnaires answered by 779 adults with myasthenia gravis shows that their fatigue (assessed by the MFI-20 score) is more often “general” or “physical” and that its level turns out to be inversely correlated with that of physical activity (SGPALS scale). Other co-factors are involved, mainly the severity of the disease and the quality of sleep. 

More than half (53%) of respondents say they are sedentary or have a low to moderate level of physical activity, below the recommendations of the World Health Organization, even though an adapted physical activity is recommended once the disease stabilized. 


Fatigue, physical activity and associated factors in 779 patients with myasthenia gravis. Andersen LK, Aadahl M, Vissing J. Neuromuscul Disord. 2021 Aug;31(8):716-725.