Evidence is accumulating that demonstrates a continued interaction between the immune system and skeletal muscle in inflammatory diseases of different pathogenic origins, in dystrophic conditions such as Duchenne muscular dystrophy as well as during normal muscle regeneration. Although a component of innate immunity, the macrophage, has been studied extensively both under pathological conditions and in cell or gene therapy strategies aimed at restoring muscle function, much less is known about dendritic cells. and their main immunological targets, T lymphocytes.
In a review published in September 2020 by a team of Brazilian and French researchers involving in particular researchers from the Institute of Myology, the focus is more particularly on dendritic cells and T lymphocytes (including effector and regulatory T lymphocytes ), highlighting the potential for interference between these cell types and their influence on the structure and function of skeletal muscle.
