French researchers from the National Reference Centre for Rare Peripheral Neuropathies in Limoges have developed a new approach to create motor neuron cell cultures from iPS cells generated from a skin sample in two patients with CMT linked to GDAP1 and 5 healthy subjects.
Morphological, immunocytological and electrophysiological analyzes show that these cultured motor neurons constitute a good tool for studying pathological cellular mechanisms and testing new therapeutic approaches, which could be reproduced in other forms of CMT.
